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Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer.
Anal Chim Acta. 2008 Feb 04; 608(1):95-103.AC

Abstract

We tried to develop a library search system using a portable, attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectrometer for on-site identification of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) tablets. The library consisted of the spectra from mixtures of controlled drugs (e.g. MDMA and ketamine), adulterants (e.g. caffeine), and diluents (e.g. lactose). In the seven library search algorithms, the derivative correlation coefficient showed the best discriminant capability. This was enhanced by segmentation of the search area. The optimized search algorithm was validated by the positive (n=154, e.g. the standard mixtures containing the controlled drug, and the MDMA/MDA tablets confiscated) and negative samples (n=56, e.g. medicinal tablets). All validation samples except for four were judged truly. Final criteria for positive identification were decided on the basis of the results of the validation. In conclusion, a portable ATR-FT-IR spectrometer with our library search system would be a useful tool for on-site identification of amphetamine-type stimulant tablets.

Authors+Show Affiliations

National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan. tujikawa@nrips.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18206999

Citation

Tsujikawa, Kenji, et al. "Development of an On-site Screening System for Amphetamine-type Stimulant Tablets With a Portable Attenuated Total Reflection Fourier Transform Infrared Spectrometer." Analytica Chimica Acta, vol. 608, no. 1, 2008, pp. 95-103.
Tsujikawa K, Kuwayama K, Miyaguchi H, et al. Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer. Anal Chim Acta. 2008;608(1):95-103.
Tsujikawa, K., Kuwayama, K., Miyaguchi, H., Kanamori, T., Iwata, Y. T., Yoshida, T., & Inoue, H. (2008). Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer. Analytica Chimica Acta, 608(1), 95-103. https://doi.org/10.1016/j.aca.2007.12.002
Tsujikawa K, et al. Development of an On-site Screening System for Amphetamine-type Stimulant Tablets With a Portable Attenuated Total Reflection Fourier Transform Infrared Spectrometer. Anal Chim Acta. 2008 Feb 4;608(1):95-103. PubMed PMID: 18206999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of an on-site screening system for amphetamine-type stimulant tablets with a portable attenuated total reflection Fourier transform infrared spectrometer. AU - Tsujikawa,Kenji, AU - Kuwayama,Kenji, AU - Miyaguchi,Hajime, AU - Kanamori,Tatsuyuki, AU - Iwata,Yuko T, AU - Yoshida,Takemi, AU - Inoue,Hiroyuki, Y1 - 2007/12/08/ PY - 2007/07/02/received PY - 2007/11/15/revised PY - 2007/12/03/accepted PY - 2008/1/22/pubmed PY - 2008/4/23/medline PY - 2008/1/22/entrez SP - 95 EP - 103 JF - Analytica chimica acta JO - Anal. Chim. Acta VL - 608 IS - 1 N2 - We tried to develop a library search system using a portable, attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectrometer for on-site identification of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) tablets. The library consisted of the spectra from mixtures of controlled drugs (e.g. MDMA and ketamine), adulterants (e.g. caffeine), and diluents (e.g. lactose). In the seven library search algorithms, the derivative correlation coefficient showed the best discriminant capability. This was enhanced by segmentation of the search area. The optimized search algorithm was validated by the positive (n=154, e.g. the standard mixtures containing the controlled drug, and the MDMA/MDA tablets confiscated) and negative samples (n=56, e.g. medicinal tablets). All validation samples except for four were judged truly. Final criteria for positive identification were decided on the basis of the results of the validation. In conclusion, a portable ATR-FT-IR spectrometer with our library search system would be a useful tool for on-site identification of amphetamine-type stimulant tablets. SN - 1873-4324 UR - https://www.unboundmedicine.com/medline/citation/18206999/Development_of_an_on_site_screening_system_for_amphetamine_type_stimulant_tablets_with_a_portable_attenuated_total_reflection_Fourier_transform_infrared_spectrometer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-2670(07)01965-4 DB - PRIME DP - Unbound Medicine ER -