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Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups.
Neuroscience. 2008 Feb 19; 151(4):1173-83.N

Abstract

The beneficial effects of exercise on learning and memory are well documented but the effects of prenatal exposure to maternal exercise on offspring are not clear yet. Using a two-trial-per-day Morris water maze for five consecutive days, succeeded by a probe trial 2 days later we showed that maternal voluntary exercise (wheel running) by pregnant rats increased the acquisition phase of the pups' learning. Maternal forced swimming by pregnant rats increased both acquisition and retention phases of the pups' learning. Also we found that the rat pups whose mother was submitted to forced-swimming during pregnancy had significantly higher brain, liver, heart and kidney weights compared with their sedentary counterparts. On the other hand we estimated the cell number of different regions of the hippocampus in the rat pups. We found that both exercise models during pregnancy increased the cell number in cornus ammonis subregion 1 (CA1) and dentate gyrus of the hippocampus in rat pups. To determine the role that noradrenergic and serotonergic neurotransmission and N-methyl-D-aspartate (NMDA) receptors hold in mediation of the maternal exercise in offspring, we used N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), p-chloroamphetamine (PCA) and MK-801 to eliminate or block the above systems, respectively. Blocking the NMDA receptors, significantly abolished learning and memory in rat pups from all three experimental groups. Elimination of noradrenergic or serotonergic input did not significantly attenuate the learning and memory in rat pups whose mothers were sedentary, while it significantly reversed the positive effects of maternal exercise during pregnancy on rat pups' learning and memory. The presented results suggest that noradrenergic and serotonergic systems in offspring brain seem to have a crucial specific role in mediating the effects of maternal physical activity during pregnancy on rat pups' cognitive function in both models of voluntary and forced exercise.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. akmaziar@sem-ums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18207332

Citation

Akhavan, M M., et al. "Serotonergic and Noradrenergic Lesions Suppress the Enhancing Effect of Maternal Exercise During Pregnancy On Learning and Memory in Rat Pups." Neuroscience, vol. 151, no. 4, 2008, pp. 1173-83.
Akhavan MM, Emami-Abarghoie M, Safari M, et al. Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. Neuroscience. 2008;151(4):1173-83.
Akhavan, M. M., Emami-Abarghoie, M., Safari, M., Sadighi-Moghaddam, B., Vafaei, A. A., Bandegi, A. R., & Rashidy-Pour, A. (2008). Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. Neuroscience, 151(4), 1173-83. https://doi.org/10.1016/j.neuroscience.2007.10.051
Akhavan MM, et al. Serotonergic and Noradrenergic Lesions Suppress the Enhancing Effect of Maternal Exercise During Pregnancy On Learning and Memory in Rat Pups. Neuroscience. 2008 Feb 19;151(4):1173-83. PubMed PMID: 18207332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups. AU - Akhavan,M M, AU - Emami-Abarghoie,M, AU - Safari,M, AU - Sadighi-Moghaddam,B, AU - Vafaei,A A, AU - Bandegi,A R, AU - Rashidy-Pour,A, Y1 - 2007/11/17/ PY - 2007/07/23/received PY - 2007/10/15/revised PY - 2008/01/13/accepted PY - 2008/1/22/pubmed PY - 2008/6/13/medline PY - 2008/1/22/entrez SP - 1173 EP - 83 JF - Neuroscience JO - Neuroscience VL - 151 IS - 4 N2 - The beneficial effects of exercise on learning and memory are well documented but the effects of prenatal exposure to maternal exercise on offspring are not clear yet. Using a two-trial-per-day Morris water maze for five consecutive days, succeeded by a probe trial 2 days later we showed that maternal voluntary exercise (wheel running) by pregnant rats increased the acquisition phase of the pups' learning. Maternal forced swimming by pregnant rats increased both acquisition and retention phases of the pups' learning. Also we found that the rat pups whose mother was submitted to forced-swimming during pregnancy had significantly higher brain, liver, heart and kidney weights compared with their sedentary counterparts. On the other hand we estimated the cell number of different regions of the hippocampus in the rat pups. We found that both exercise models during pregnancy increased the cell number in cornus ammonis subregion 1 (CA1) and dentate gyrus of the hippocampus in rat pups. To determine the role that noradrenergic and serotonergic neurotransmission and N-methyl-D-aspartate (NMDA) receptors hold in mediation of the maternal exercise in offspring, we used N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), p-chloroamphetamine (PCA) and MK-801 to eliminate or block the above systems, respectively. Blocking the NMDA receptors, significantly abolished learning and memory in rat pups from all three experimental groups. Elimination of noradrenergic or serotonergic input did not significantly attenuate the learning and memory in rat pups whose mothers were sedentary, while it significantly reversed the positive effects of maternal exercise during pregnancy on rat pups' learning and memory. The presented results suggest that noradrenergic and serotonergic systems in offspring brain seem to have a crucial specific role in mediating the effects of maternal physical activity during pregnancy on rat pups' cognitive function in both models of voluntary and forced exercise. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/18207332/Serotonergic_and_noradrenergic_lesions_suppress_the_enhancing_effect_of_maternal_exercise_during_pregnancy_on_learning_and_memory_in_rat_pups_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(07)01339-5 DB - PRIME DP - Unbound Medicine ER -