Tags

Type your tag names separated by a space and hit enter

Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics.
Clin Endocrinol (Oxf) 2008; 69(1):29-35CE

Abstract

BACKGROUND

Vitamin D insufficiency is very common and is known to cause secondary hyperparathyroidism (SHPT). However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT).

AIM

We compared indices of calcium homeostasis, bone metabolism and body composition in subjects with differential PTH responses to low vitamin D levels.

DESIGN

Cross-sectional study. In 405 recent postmenopausal women with vitamin D insufficiency, we compared levels of bone turnover markers, bone mineral density (BMD), body composition, and body weight between subjects with SHPT and FHPT.

RESULTS

Plasma 25-hydroxyvitamin D (P-25OHD) levels were slightly higher (P < 0.05) in SHPT compared with FHPT. SHPT was associated with higher levels of osteocalcin and bone-specific alkaline phosphatase, whereas whole body BMD and hip- and lumbar spine-BMD were significantly reduced. Subjects with SHPT had a 7% (P < 0.01) higher body weight and a 23% higher fat mass (P < 0.01) than subjects with FHPT, whereas lean tissue mass did not differ between groups. In SHPT, fat mass was increased by 14% (P < 0.001) at the upper and lower extremities and by 33% (P < 0.001) at the trunk. In a regression model, significant predictors of fat mass was P-PTH (r(p) = 0.248, P < 0.01) and P-osteocalcin (r(p) = -0.115, P = 0.02), with no effects of P-25OHD or P-creatinine levels.

CONCLUSIONS

Effects of vitamin D insufficiency on bone is associated with the PTH responses. The increased body weight and fat mass in SHPT compared with FHPT may imply that PTH excess contributes to fat accumulation.

Authors+Show Affiliations

Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark. rejnmark@post6.tele.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18208576

Citation

Rejnmark, Lars, et al. "Parathyroid Response to Vitamin D Insufficiency: Relations to Bone, Body Composition and to Lifestyle Characteristics." Clinical Endocrinology, vol. 69, no. 1, 2008, pp. 29-35.
Rejnmark L, Vestergaard P, Brot C, et al. Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics. Clin Endocrinol (Oxf). 2008;69(1):29-35.
Rejnmark, L., Vestergaard, P., Brot, C., & Mosekilde, L. (2008). Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics. Clinical Endocrinology, 69(1), pp. 29-35. doi:10.1111/j.1365-2265.2008.03186.x.
Rejnmark L, et al. Parathyroid Response to Vitamin D Insufficiency: Relations to Bone, Body Composition and to Lifestyle Characteristics. Clin Endocrinol (Oxf). 2008;69(1):29-35. PubMed PMID: 18208576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parathyroid response to vitamin D insufficiency: relations to bone, body composition and to lifestyle characteristics. AU - Rejnmark,Lars, AU - Vestergaard,Peter, AU - Brot,Christine, AU - Mosekilde,Leif, Y1 - 2008/07/01/ PY - 2008/1/23/pubmed PY - 2009/7/25/medline PY - 2008/1/23/entrez SP - 29 EP - 35 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 69 IS - 1 N2 - BACKGROUND: Vitamin D insufficiency is very common and is known to cause secondary hyperparathyroidism (SHPT). However, in some subjects the PTH response to low vitamin D levels is blunted, which has been termed functional hypoparathyroidism (FHPT). AIM: We compared indices of calcium homeostasis, bone metabolism and body composition in subjects with differential PTH responses to low vitamin D levels. DESIGN: Cross-sectional study. In 405 recent postmenopausal women with vitamin D insufficiency, we compared levels of bone turnover markers, bone mineral density (BMD), body composition, and body weight between subjects with SHPT and FHPT. RESULTS: Plasma 25-hydroxyvitamin D (P-25OHD) levels were slightly higher (P < 0.05) in SHPT compared with FHPT. SHPT was associated with higher levels of osteocalcin and bone-specific alkaline phosphatase, whereas whole body BMD and hip- and lumbar spine-BMD were significantly reduced. Subjects with SHPT had a 7% (P < 0.01) higher body weight and a 23% higher fat mass (P < 0.01) than subjects with FHPT, whereas lean tissue mass did not differ between groups. In SHPT, fat mass was increased by 14% (P < 0.001) at the upper and lower extremities and by 33% (P < 0.001) at the trunk. In a regression model, significant predictors of fat mass was P-PTH (r(p) = 0.248, P < 0.01) and P-osteocalcin (r(p) = -0.115, P = 0.02), with no effects of P-25OHD or P-creatinine levels. CONCLUSIONS: Effects of vitamin D insufficiency on bone is associated with the PTH responses. The increased body weight and fat mass in SHPT compared with FHPT may imply that PTH excess contributes to fat accumulation. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/18208576/Parathyroid_response_to_vitamin_D_insufficiency:_relations_to_bone_body_composition_and_to_lifestyle_characteristics_ L2 - https://doi.org/10.1111/j.1365-2265.2008.03186.x DB - PRIME DP - Unbound Medicine ER -