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CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis.
Mult Scler. 2008 May; 14(4):446-54.MS

Abstract

Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting (RR) MS patients classified according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Sixty-four patients with other inflammatory neurological disorders (OIND) and 64 subjects with noninflammatory neurological disorders (NIND) served as controls. CSF concentrations were higher in RRMS and in OIND than in NIND patients for sHLA-I (P < 0.02), greater in RRMS than in OIND and in NIND for sHLA-G (P < 0.001 and P < 0.01, respectively) and lower in RRMS than in OIND and in NIND for sFas (P < 0.001 and P < 0.02, respectively). An increase in CSF levels was identified in MRI active RRMS for sHLA-I (P < 0.01) and in MRI stable RRMS for sHLA-G (P < 0.01), whereas CSF values of sFas were decreased in RRMS without Gd-enhancing lesions (P < 0.02). In MS patients with no evidence of MRI disease activity, a trend towards an inverse correlation was found between CSF concentrations of sHLA-G and sHLA-I and between CSF levels of sHLA-G and sFas. Our results indicate that enhanced CSF levels of sHLA-I antigens most likely represent an indirect manifestation of intrathecal immune activation taking place in neuroinflammation. Conversely, reciprocal fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in MS through Fas/FasL-mediated mechanisms.

Authors+Show Affiliations

Multiple Sclerosis Center, Section of Neurology, University of Ferrara, Arcispedale S. Anna, Corso della Giovecca 203, Ferrara I-44100, Italy. henryfai@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18208868

Citation

Fainardi, E, et al. "CSF Levels of Soluble HLA-G and Fas Molecules Are Inversely Associated to MRI Evidence of Disease Activity in Patients With Relapsing-remitting Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 14, no. 4, 2008, pp. 446-54.
Fainardi E, Rizzo R, Melchiorri L, et al. CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis. Mult Scler. 2008;14(4):446-54.
Fainardi, E., Rizzo, R., Melchiorri, L., Stignani, M., Castellazzi, M., Tamborino, C., Paolino, E., Tola, M. R., Granieri, E., & Baricordi, O. R. (2008). CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 14(4), 446-54. https://doi.org/10.1177/1352458507085137
Fainardi E, et al. CSF Levels of Soluble HLA-G and Fas Molecules Are Inversely Associated to MRI Evidence of Disease Activity in Patients With Relapsing-remitting Multiple Sclerosis. Mult Scler. 2008;14(4):446-54. PubMed PMID: 18208868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing-remitting multiple sclerosis. AU - Fainardi,E, AU - Rizzo,R, AU - Melchiorri,L, AU - Stignani,M, AU - Castellazzi,M, AU - Tamborino,C, AU - Paolino,E, AU - Tola,M R, AU - Granieri,E, AU - Baricordi,O R, Y1 - 2008/01/21/ PY - 2008/1/23/pubmed PY - 2008/10/22/medline PY - 2008/1/23/entrez SP - 446 EP - 54 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult Scler VL - 14 IS - 4 N2 - Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting (RR) MS patients classified according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Sixty-four patients with other inflammatory neurological disorders (OIND) and 64 subjects with noninflammatory neurological disorders (NIND) served as controls. CSF concentrations were higher in RRMS and in OIND than in NIND patients for sHLA-I (P < 0.02), greater in RRMS than in OIND and in NIND for sHLA-G (P < 0.001 and P < 0.01, respectively) and lower in RRMS than in OIND and in NIND for sFas (P < 0.001 and P < 0.02, respectively). An increase in CSF levels was identified in MRI active RRMS for sHLA-I (P < 0.01) and in MRI stable RRMS for sHLA-G (P < 0.01), whereas CSF values of sFas were decreased in RRMS without Gd-enhancing lesions (P < 0.02). In MS patients with no evidence of MRI disease activity, a trend towards an inverse correlation was found between CSF concentrations of sHLA-G and sHLA-I and between CSF levels of sHLA-G and sFas. Our results indicate that enhanced CSF levels of sHLA-I antigens most likely represent an indirect manifestation of intrathecal immune activation taking place in neuroinflammation. Conversely, reciprocal fluctuations in CSF sHLA-G and sFas levels observed when MRI disease activity resolved suggest that sHLA-G could play an immunomodulatory role in MS through Fas/FasL-mediated mechanisms. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/18208868/CSF_levels_of_soluble_HLA_G_and_Fas_molecules_are_inversely_associated_to_MRI_evidence_of_disease_activity_in_patients_with_relapsing_remitting_multiple_sclerosis_ L2 - https://journals.sagepub.com/doi/10.1177/1352458507085137?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -