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Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis.
Mult Scler. 2008 May; 14(4):433-9.MS

Abstract

OBJECTIVE

The aim of this study was to determine if multiple sclerosis (MS) shows association with variants of single nucleotide polymorphisms (SNP) within chromosome 19p, where previous studies resulted in conflicting observations. Subjects and methods The transmissions of 569 SNP variants and 608 haplotypes from unaffected parents to their affected children were tested in 257 Caucasian families by using the pedigree disequilibrium test (PDT), the TRANSMIT version 2.5 program and the family- and haplotype-based association tests (FBAT and HBAT). The distribution of linkage disequilibrium (LD) among SNPs in 19p was assessed by ldmax and correlated with the location of MS-associated haplotypes.

RESULTS

Individual SNP alleles did not show association after correction for multiple testing in PDT. Several marker haplotypes within potential candidate genes of intracellular enzymes, transmembrane proteins and receptors and signaling and adhesion molecules appeared to be weakly associated with the disease in both TRANSMIT and HBAT. However, none of the associations was strong enough to survive correction for multiple testing.

CONCLUSIONS

The present study is in the line of previous studies with negative conclusions concerning the role of the 19p region in MS.

Authors+Show Affiliations

VAMC, SUNY Upstate Medical University, 800 Irving Avenue, Research (151), Syracuse, NY 13210, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18208878

Citation

Vyshkina, T, and B Kalman. "Linkage Disequilibrium Analyses Within Chromosome 19p in Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 14, no. 4, 2008, pp. 433-9.
Vyshkina T, Kalman B. Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis. Mult Scler. 2008;14(4):433-9.
Vyshkina, T., & Kalman, B. (2008). Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 14(4), 433-9. https://doi.org/10.1177/1352458507084267
Vyshkina T, Kalman B. Linkage Disequilibrium Analyses Within Chromosome 19p in Multiple Sclerosis. Mult Scler. 2008;14(4):433-9. PubMed PMID: 18208878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis. AU - Vyshkina,T, AU - Kalman,B, Y1 - 2008/01/21/ PY - 2008/1/23/pubmed PY - 2008/10/22/medline PY - 2008/1/23/entrez SP - 433 EP - 9 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 14 IS - 4 N2 - OBJECTIVE: The aim of this study was to determine if multiple sclerosis (MS) shows association with variants of single nucleotide polymorphisms (SNP) within chromosome 19p, where previous studies resulted in conflicting observations. Subjects and methods The transmissions of 569 SNP variants and 608 haplotypes from unaffected parents to their affected children were tested in 257 Caucasian families by using the pedigree disequilibrium test (PDT), the TRANSMIT version 2.5 program and the family- and haplotype-based association tests (FBAT and HBAT). The distribution of linkage disequilibrium (LD) among SNPs in 19p was assessed by ldmax and correlated with the location of MS-associated haplotypes. RESULTS: Individual SNP alleles did not show association after correction for multiple testing in PDT. Several marker haplotypes within potential candidate genes of intracellular enzymes, transmembrane proteins and receptors and signaling and adhesion molecules appeared to be weakly associated with the disease in both TRANSMIT and HBAT. However, none of the associations was strong enough to survive correction for multiple testing. CONCLUSIONS: The present study is in the line of previous studies with negative conclusions concerning the role of the 19p region in MS. SN - 1352-4585 UR - https://www.unboundmedicine.com/medline/citation/18208878/Linkage_disequilibrium_analyses_within_chromosome_19p_in_multiple_sclerosis_ L2 - http://journals.sagepub.com/doi/full/10.1177/1352458507084267?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -