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Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats.
J Psychopharmacol. 2008 Nov; 22(8):918-22.JP

Abstract

Gender differences in psychiatric research are becoming more widely recognized, and changes in levels of the steroid hormone, oestrogen, over the menstrual or oestrous cycle are becoming increasingly implicated in alterations in cognitive strategies and capacities. The aim of this study is to investigate the interaction between oestrogen, NMDA receptor function and cognitive processing in rats. Forty-five mature female hooded-Lister rats received vehicle, 0.5, 5 or 10 microg/kg of oestradiol benzoate (EB, s.c. in olive oil) 24 h prior to an acute dose of 2 mg/kg phencyclidine (PCP, i.p. in 0.9% w/v saline), or vehicle (0.9% saline). After 30 min following PCP treatment, animals completed the novel object recognition task with a 1 min inter-trial interval to assess object recognition memory. Results show that 5 and 10 microg/kg of EB 24 h prior to 2 mg/kg PCP significantly (P < 0.01 and < 0.001, respectively) protected against the cognitive impairing effect of PCP in contrast to vehicle and 0.5 microg/kg EB plus PCP (not significant). EB may exert a neuromodulatory effect in this animal model leading to attenuation of the PCP-induced impairment in object recognition memory, suggesting an interaction between the gonadal steroids and NMDA receptor-mediated cognitive dysfunction, which is of potential relevance to schizophrenia.

Authors+Show Affiliations

School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18208936

Citation

Sutcliffe, J S., et al. "Oestradiol Attenuates the Cognitive Deficit Induced By Acute Phencyclidine Treatment in Mature Female hooded-Lister Rats." Journal of Psychopharmacology (Oxford, England), vol. 22, no. 8, 2008, pp. 918-22.
Sutcliffe JS, Rhaman F, Marshall KM, et al. Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats. J Psychopharmacol. 2008;22(8):918-22.
Sutcliffe, J. S., Rhaman, F., Marshall, K. M., & Neill, J. C. (2008). Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats. Journal of Psychopharmacology (Oxford, England), 22(8), 918-22. https://doi.org/10.1177/0269881107083839
Sutcliffe JS, et al. Oestradiol Attenuates the Cognitive Deficit Induced By Acute Phencyclidine Treatment in Mature Female hooded-Lister Rats. J Psychopharmacol. 2008;22(8):918-22. PubMed PMID: 18208936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oestradiol attenuates the cognitive deficit induced by acute phencyclidine treatment in mature female hooded-Lister rats. AU - Sutcliffe,J S, AU - Rhaman,F, AU - Marshall,K M, AU - Neill,J C, Y1 - 2008/01/21/ PY - 2008/1/23/pubmed PY - 2009/1/14/medline PY - 2008/1/23/entrez SP - 918 EP - 22 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 22 IS - 8 N2 - Gender differences in psychiatric research are becoming more widely recognized, and changes in levels of the steroid hormone, oestrogen, over the menstrual or oestrous cycle are becoming increasingly implicated in alterations in cognitive strategies and capacities. The aim of this study is to investigate the interaction between oestrogen, NMDA receptor function and cognitive processing in rats. Forty-five mature female hooded-Lister rats received vehicle, 0.5, 5 or 10 microg/kg of oestradiol benzoate (EB, s.c. in olive oil) 24 h prior to an acute dose of 2 mg/kg phencyclidine (PCP, i.p. in 0.9% w/v saline), or vehicle (0.9% saline). After 30 min following PCP treatment, animals completed the novel object recognition task with a 1 min inter-trial interval to assess object recognition memory. Results show that 5 and 10 microg/kg of EB 24 h prior to 2 mg/kg PCP significantly (P < 0.01 and < 0.001, respectively) protected against the cognitive impairing effect of PCP in contrast to vehicle and 0.5 microg/kg EB plus PCP (not significant). EB may exert a neuromodulatory effect in this animal model leading to attenuation of the PCP-induced impairment in object recognition memory, suggesting an interaction between the gonadal steroids and NMDA receptor-mediated cognitive dysfunction, which is of potential relevance to schizophrenia. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/18208936/Oestradiol_attenuates_the_cognitive_deficit_induced_by_acute_phencyclidine_treatment_in_mature_female_hooded_Lister_rats_ L2 - https://journals.sagepub.com/doi/10.1177/0269881107083839?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -