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Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid.
Arch Dermatol. 2008 Jan; 144(1):41-8.AD

Abstract

OBJECTIVE

To determine the prevalence, immunoglobulin subclass distribution, and clinical correlation of antibodies (Abs), especially of IgE Abs, to BP180 and BP230 in patients with bullous pemphigoid (BP).

DESIGN

Retrospective case series analysis.

SETTING

Department of Dermatology, Nagasaki University Graduate School of Biomedical Science.

PATIENTS

Serum samples from 37 patients with BP, 6 with pemphigus vulgaris, 5 with pemphigus foliaceus, and 26 healthy controls (n = 26) were examined by enzyme-linked immunosorbent assay.

MAIN OUTCOME MEASURES

Prevalence, immunoglobulin subclass distribution, and clinical correlation of Abs, especially of IgE Abs, to BP180 and BP230.

RESULTS

IgG anti-BP180 and anti-BP230 Abs were detected in 35 (95%) and 26 (70%) of the 37 BP serum samples, respectively. IgG1 and IgG4 isotypes were positive in 32 (87%) and 25 (68%), respectively, of the BP serum samples for anti-BP180 Abs, while they were detected in 16 (44%) and 26 (70%), respectively, for anti-BP230 Abs. IgE anti-BP180 and anti-BP230 Abs were equally detected in 8 (22%) of the BP serum samples. Similar to IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs was associated with broader skin lesions. Furthermore, patients with BP positive for IgE anti-BP180 Abs required longer duration for remission, higher dosage of prednisolone, and more intensive therapies for remission. By contrast, this was not true for those with of IgE anti-BP230 Abs. Remarkably, when analyzed in patients with BP who had a high titer of IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs, but not IgG anti-BP180 Abs, were associated with a more severe form.

CONCLUSIONS

The present study suggests that IgE anti-BP180 Abs are related to the disease severity and activity of BP. Moreover, it may be possible to identify treatment-refractory patients with BP more specifically by assessing the presence or levels of IgE anti-BP180 Abs in those with a high IgG anti-BP180 Ab titer.

Authors+Show Affiliations

Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. s-sato@nagasaki-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18209167

Citation

Iwata, Yohei, et al. "Correlation of IgE Autoantibody to BP180 With a Severe Form of Bullous Pemphigoid." Archives of Dermatology, vol. 144, no. 1, 2008, pp. 41-8.
Iwata Y, Komura K, Kodera M, et al. Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid. Arch Dermatol. 2008;144(1):41-8.
Iwata, Y., Komura, K., Kodera, M., Usuda, T., Yokoyama, Y., Hara, T., Muroi, E., Ogawa, F., Takenaka, M., & Sato, S. (2008). Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid. Archives of Dermatology, 144(1), 41-8. https://doi.org/10.1001/archdermatol.2007.9
Iwata Y, et al. Correlation of IgE Autoantibody to BP180 With a Severe Form of Bullous Pemphigoid. Arch Dermatol. 2008;144(1):41-8. PubMed PMID: 18209167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of IgE autoantibody to BP180 with a severe form of bullous pemphigoid. AU - Iwata,Yohei, AU - Komura,Kazuhiro, AU - Kodera,Masanari, AU - Usuda,Toshikazu, AU - Yokoyama,Yoko, AU - Hara,Toshihide, AU - Muroi,Eiji, AU - Ogawa,Fumihide, AU - Takenaka,Motoi, AU - Sato,Shinichi, PY - 2008/1/23/pubmed PY - 2008/2/6/medline PY - 2008/1/23/entrez SP - 41 EP - 8 JF - Archives of dermatology JO - Arch Dermatol VL - 144 IS - 1 N2 - OBJECTIVE: To determine the prevalence, immunoglobulin subclass distribution, and clinical correlation of antibodies (Abs), especially of IgE Abs, to BP180 and BP230 in patients with bullous pemphigoid (BP). DESIGN: Retrospective case series analysis. SETTING: Department of Dermatology, Nagasaki University Graduate School of Biomedical Science. PATIENTS: Serum samples from 37 patients with BP, 6 with pemphigus vulgaris, 5 with pemphigus foliaceus, and 26 healthy controls (n = 26) were examined by enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES: Prevalence, immunoglobulin subclass distribution, and clinical correlation of Abs, especially of IgE Abs, to BP180 and BP230. RESULTS: IgG anti-BP180 and anti-BP230 Abs were detected in 35 (95%) and 26 (70%) of the 37 BP serum samples, respectively. IgG1 and IgG4 isotypes were positive in 32 (87%) and 25 (68%), respectively, of the BP serum samples for anti-BP180 Abs, while they were detected in 16 (44%) and 26 (70%), respectively, for anti-BP230 Abs. IgE anti-BP180 and anti-BP230 Abs were equally detected in 8 (22%) of the BP serum samples. Similar to IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs was associated with broader skin lesions. Furthermore, patients with BP positive for IgE anti-BP180 Abs required longer duration for remission, higher dosage of prednisolone, and more intensive therapies for remission. By contrast, this was not true for those with of IgE anti-BP230 Abs. Remarkably, when analyzed in patients with BP who had a high titer of IgG anti-BP180 Abs, the presence or levels of IgE anti-BP180 Abs, but not IgG anti-BP180 Abs, were associated with a more severe form. CONCLUSIONS: The present study suggests that IgE anti-BP180 Abs are related to the disease severity and activity of BP. Moreover, it may be possible to identify treatment-refractory patients with BP more specifically by assessing the presence or levels of IgE anti-BP180 Abs in those with a high IgG anti-BP180 Ab titer. SN - 1538-3652 UR - https://www.unboundmedicine.com/medline/citation/18209167/Correlation_of_IgE_autoantibody_to_BP180_with_a_severe_form_of_bullous_pemphigoid_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archdermatol.2007.9 DB - PRIME DP - Unbound Medicine ER -