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[The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease].
Rinsho Shinkeigaku. 2007 Nov; 47(11):774-8.RS

Abstract

Parkinson's disease (PD) is a progressive movement disorder characterized by resting tremor, rigidity, akinesia, and postural instability. In addition, PD is characterized by the appearance of Lewy bodies in the remaining neurons. The exact etiology for this disease is still unknown. However, genetic-environmental interaction could contribute the pathomechanisms of PD. Indeed, totally seven causative genes responsible for familial PD have been identified. Since discovery of familial PD (FPD), genetic PD models have been developed. Thus, we think that the research field of FPD provides us a good hint for the pathogenesis of nigral degeneration in not only familial but also sporadic form of PD.

Authors+Show Affiliations

Department of Neurology, Juntendo University School of Medicine.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

18210796

Citation

Hattori, Nobutaka, and Shin-ichiro Kubo. "[The Pathogenesis of Parkinson's Disease: a Hint From Insights of Familial Parkinson's Disease]." Rinsho Shinkeigaku = Clinical Neurology, vol. 47, no. 11, 2007, pp. 774-8.
Hattori N, Kubo S. [The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease]. Rinsho Shinkeigaku. 2007;47(11):774-8.
Hattori, N., & Kubo, S. (2007). [The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease]. Rinsho Shinkeigaku = Clinical Neurology, 47(11), 774-8.
Hattori N, Kubo S. [The Pathogenesis of Parkinson's Disease: a Hint From Insights of Familial Parkinson's Disease]. Rinsho Shinkeigaku. 2007;47(11):774-8. PubMed PMID: 18210796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The pathogenesis of Parkinson's disease: a hint from insights of familial Parkinson's disease]. AU - Hattori,Nobutaka, AU - Kubo,Shin-ichiro, PY - 2008/1/24/pubmed PY - 2008/4/5/medline PY - 2008/1/24/entrez SP - 774 EP - 8 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 47 IS - 11 N2 - Parkinson's disease (PD) is a progressive movement disorder characterized by resting tremor, rigidity, akinesia, and postural instability. In addition, PD is characterized by the appearance of Lewy bodies in the remaining neurons. The exact etiology for this disease is still unknown. However, genetic-environmental interaction could contribute the pathomechanisms of PD. Indeed, totally seven causative genes responsible for familial PD have been identified. Since discovery of familial PD (FPD), genetic PD models have been developed. Thus, we think that the research field of FPD provides us a good hint for the pathogenesis of nigral degeneration in not only familial but also sporadic form of PD. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/18210796/[The_pathogenesis_of_Parkinson's_disease:_a_hint_from_insights_of_familial_Parkinson's_disease]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -
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