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[Functional mapping of dopaminergic transmission].
Rinsho Shinkeigaku. 2007 Nov; 47(11):832-4.RS

Abstract

Patients with Parkinson's disease (PD) are impaired when performing cognitive tasks such as mental operations and working memory paradigms, which engage frontal lobe regions. These impairments may reflect degeneration of either nigrostriatal or mesocortical dopaminergic projections. D2 receptor antagonist 11C-raclopride (RAC) with positron emission tomography (PET) now provides an in vivo approach for investigating dopaminergic transmission by monitoring changes in synaptic dopamine levels during task performance, Our RAC PET study suggests that the capacity to release dopamine during a working memory task is impaired in the striatum but relatively preserved in the medial prefrontal cortex in patients with PD. This pattern of dopamine release is in accordance with our previous H2(15)O PET findings showing hypoactivity of the striatum during a mental operation task in PD. These PET findings support a view that degeneration of nigrostriatal dopaminergic projection causing disruption of the cortico-basal ganglia circuit contributes to the cognitive impairments observed in PD. The findings also implicates that mesocortical dopaminergic function may be preserved in PD. Since excessive stimulation of dopamine receptors in the frontal cortex can rather deteriorate its function, the benefit in the striatum and the risk in the frontal cortex should be properly evaluated for dopamine replacement therapy.

Authors+Show Affiliations

Human Brain Research Center, Kyoto University Graduate School of Medicine.

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

18210810

Citation

Sawamoto, Nobukatsu. "[Functional Mapping of Dopaminergic Transmission]." Rinsho Shinkeigaku = Clinical Neurology, vol. 47, no. 11, 2007, pp. 832-4.
Sawamoto N. [Functional mapping of dopaminergic transmission]. Rinsho Shinkeigaku. 2007;47(11):832-4.
Sawamoto, N. (2007). [Functional mapping of dopaminergic transmission]. Rinsho Shinkeigaku = Clinical Neurology, 47(11), 832-4.
Sawamoto N. [Functional Mapping of Dopaminergic Transmission]. Rinsho Shinkeigaku. 2007;47(11):832-4. PubMed PMID: 18210810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Functional mapping of dopaminergic transmission]. A1 - Sawamoto,Nobukatsu, PY - 2008/1/24/pubmed PY - 2008/4/5/medline PY - 2008/1/24/entrez SP - 832 EP - 4 JF - Rinsho shinkeigaku = Clinical neurology JO - Rinsho Shinkeigaku VL - 47 IS - 11 N2 - Patients with Parkinson's disease (PD) are impaired when performing cognitive tasks such as mental operations and working memory paradigms, which engage frontal lobe regions. These impairments may reflect degeneration of either nigrostriatal or mesocortical dopaminergic projections. D2 receptor antagonist 11C-raclopride (RAC) with positron emission tomography (PET) now provides an in vivo approach for investigating dopaminergic transmission by monitoring changes in synaptic dopamine levels during task performance, Our RAC PET study suggests that the capacity to release dopamine during a working memory task is impaired in the striatum but relatively preserved in the medial prefrontal cortex in patients with PD. This pattern of dopamine release is in accordance with our previous H2(15)O PET findings showing hypoactivity of the striatum during a mental operation task in PD. These PET findings support a view that degeneration of nigrostriatal dopaminergic projection causing disruption of the cortico-basal ganglia circuit contributes to the cognitive impairments observed in PD. The findings also implicates that mesocortical dopaminergic function may be preserved in PD. Since excessive stimulation of dopamine receptors in the frontal cortex can rather deteriorate its function, the benefit in the striatum and the risk in the frontal cortex should be properly evaluated for dopamine replacement therapy. SN - 0009-918X UR - https://www.unboundmedicine.com/medline/citation/18210810/[Functional_mapping_of_dopaminergic_transmission]_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -