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Berry fruit supplementation and the aging brain.
J Agric Food Chem. 2008 Feb 13; 56(3):636-41.JA

Abstract

The onset of age-related neurodegenerative diseases such as Alzheimer's or Parkinson's disease, superimposed on a declining nervous system, could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. In cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related decrements in neuronal function, health-care costs will continue to rise exponentially. Thus, it is extremely important to explore methods to retard or reverse age-related neuronal deficits, as well as their subsequent behavioral manifestations, to increase healthy aging. In this regard, consumption of diets rich in antioxidants and anti-inflammatory polyphenolics, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases. Research suggests that the polyphenolic compounds found in berry fruits, such as blueberries and strawberries, may exert their beneficial effects either through their ability to lower oxidative stress and inflammation or directly by altering the signaling involved in neuronal communication, calcium buffering ability, neuroprotective stress shock proteins, plasticity, and stress signaling pathways. These interventions, in turn, may exert protection against age-related deficits in cognitive and motor function. The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits.

Authors+Show Affiliations

USDA-ARS Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. barbara.shukitt-hale@ars.usda.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18211020

Citation

Shukitt-Hale, Barbara, et al. "Berry Fruit Supplementation and the Aging Brain." Journal of Agricultural and Food Chemistry, vol. 56, no. 3, 2008, pp. 636-41.
Shukitt-Hale B, Lau FC, Joseph JA. Berry fruit supplementation and the aging brain. J Agric Food Chem. 2008;56(3):636-41.
Shukitt-Hale, B., Lau, F. C., & Joseph, J. A. (2008). Berry fruit supplementation and the aging brain. Journal of Agricultural and Food Chemistry, 56(3), 636-41. https://doi.org/10.1021/jf072505f
Shukitt-Hale B, Lau FC, Joseph JA. Berry Fruit Supplementation and the Aging Brain. J Agric Food Chem. 2008 Feb 13;56(3):636-41. PubMed PMID: 18211020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Berry fruit supplementation and the aging brain. AU - Shukitt-Hale,Barbara, AU - Lau,Francis C, AU - Joseph,James A, Y1 - 2008/01/23/ PY - 2008/1/24/pubmed PY - 2008/4/25/medline PY - 2008/1/24/entrez SP - 636 EP - 41 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 3 N2 - The onset of age-related neurodegenerative diseases such as Alzheimer's or Parkinson's disease, superimposed on a declining nervous system, could exacerbate the motor and cognitive behavioral deficits that normally occur in senescence. In cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related decrements in neuronal function, health-care costs will continue to rise exponentially. Thus, it is extremely important to explore methods to retard or reverse age-related neuronal deficits, as well as their subsequent behavioral manifestations, to increase healthy aging. In this regard, consumption of diets rich in antioxidants and anti-inflammatory polyphenolics, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases. Research suggests that the polyphenolic compounds found in berry fruits, such as blueberries and strawberries, may exert their beneficial effects either through their ability to lower oxidative stress and inflammation or directly by altering the signaling involved in neuronal communication, calcium buffering ability, neuroprotective stress shock proteins, plasticity, and stress signaling pathways. These interventions, in turn, may exert protection against age-related deficits in cognitive and motor function. The purpose of this paper is to discuss the benefits of these interventions in rodent models and to describe the putative molecular mechanisms involved in their benefits. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/18211020/Berry_fruit_supplementation_and_the_aging_brain_ L2 - https://doi.org/10.1021/jf072505f DB - PRIME DP - Unbound Medicine ER -