Tags

Type your tag names separated by a space and hit enter

Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream.
J Agric Food Chem. 2008 Feb 13; 56(3):713-9.JA

Abstract

Plasma and urine were collected over a 24 h period after the consumption by humans of 200 g of strawberries, containing 222 micromol of pelargonidin-3- O-glucoside, with and without cream. The main metabolite, a pelargonidin- O-glucuronide, reached a peak plasma concentration (C max) of 274 +/- 24 nmol/L after 1.1 +/- 0.4 h (t max) when only strawberries were ingested. When the strawberries were eaten with cream, the C max was not statistically different but the t max at 2.4 +/- 0.5 h was delayed significantly (p < 0.001). The pelargonidin- O-glucuronide, along with smaller quantities of other metabolites, was also excreted in urine in quantities corresponding to ca. 1% of anthocyanin intake. The quantities excreted over the 0-24 h collection period were not influenced significantly by cream. However, the 0-2 h excretion of anthocyanin metabolites was significantly lower when the strawberries were eaten with cream, whereas the reverse occurred during with the 5-8 h excretion period. In keeping with these observations, measurement of plasma paracetamol and breath hydrogen revealed that cream delayed gastric emptying and extended mouth to cecum transit time.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Mullen W
Plant Products and Human Nutrition Group, Graham Kerr Building, Division of Environmental and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Edwards CA
No affiliation info available
Serafini M
No affiliation info available
Crozier A
No affiliation info available

MeSH

AdultAnimalsAnthocyaninsBiological AvailabilityDietFemaleFragariaFruitGastric EmptyingGastrointestinal TransitGlucuronidesHumansMaleMiddle AgedMilk

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18211024

Citation

Mullen, William, et al. "Bioavailability of pelargonidin-3-O-glucoside and Its Metabolites in Humans Following the Ingestion of Strawberries With and Without Cream." Journal of Agricultural and Food Chemistry, vol. 56, no. 3, 2008, pp. 713-9.
Mullen W, Edwards CA, Serafini M, et al. Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. J Agric Food Chem. 2008;56(3):713-9.
Mullen, W., Edwards, C. A., Serafini, M., & Crozier, A. (2008). Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. Journal of Agricultural and Food Chemistry, 56(3), 713-9. https://doi.org/10.1021/jf072000p
Mullen W, et al. Bioavailability of pelargonidin-3-O-glucoside and Its Metabolites in Humans Following the Ingestion of Strawberries With and Without Cream. J Agric Food Chem. 2008 Feb 13;56(3):713-9. PubMed PMID: 18211024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. AU - Mullen,William, AU - Edwards,Christine A, AU - Serafini,Mauro, AU - Crozier,Alan, Y1 - 2008/01/23/ PY - 2008/1/24/pubmed PY - 2008/4/25/medline PY - 2008/1/24/entrez SP - 713 EP - 9 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 3 N2 - Plasma and urine were collected over a 24 h period after the consumption by humans of 200 g of strawberries, containing 222 micromol of pelargonidin-3- O-glucoside, with and without cream. The main metabolite, a pelargonidin- O-glucuronide, reached a peak plasma concentration (C max) of 274 +/- 24 nmol/L after 1.1 +/- 0.4 h (t max) when only strawberries were ingested. When the strawberries were eaten with cream, the C max was not statistically different but the t max at 2.4 +/- 0.5 h was delayed significantly (p < 0.001). The pelargonidin- O-glucuronide, along with smaller quantities of other metabolites, was also excreted in urine in quantities corresponding to ca. 1% of anthocyanin intake. The quantities excreted over the 0-24 h collection period were not influenced significantly by cream. However, the 0-2 h excretion of anthocyanin metabolites was significantly lower when the strawberries were eaten with cream, whereas the reverse occurred during with the 5-8 h excretion period. In keeping with these observations, measurement of plasma paracetamol and breath hydrogen revealed that cream delayed gastric emptying and extended mouth to cecum transit time. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/18211024/Bioavailability_of_pelargonidin_3_O_glucoside_and_its_metabolites_in_humans_following_the_ingestion_of_strawberries_with_and_without_cream_ DB - PRIME DP - Unbound Medicine ER -