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Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage.
J Physiol Pharmacol 2007; 58 Suppl 6:5-22JP

Abstract

Melatonin and its metabolites are potent antioxidants by virtue of their ability to scavenge both oxygen-based and nitrogen-based radicals and intermediates but also as a consequence of their ability to stimulate the activity of antioxidative enzymes. Melatonin also prevents electron leakage from the mitochondrial electron transport chain thereby diminishing free radical generation; this process is referred to as radical avoidance. The fact that melatonin and its metabolites are all efficient radical scavengers indicates that melatonin is a precursor molecule for a variety of intracellular reducing agents. In specific reference to the brain, melatonin also has an advantage over some other antioxidants given that it readily passes through the blood-brain-barrier. This, coupled with the fact that it and its by-products are particularly efficient detoxifiers of reactive species, make these molecules of major importance in protecting the brain from oxidative/nitrosative abuse. This review summarizes the literature on two brain-related situations, i.e., traumatic brain and spinal cord injury and ischemia/reperfusion, and the neurodegenerative disease, amyotrophic lateral sclerosis, where melatonin has been shown to have efficacy in abating neural damage. These, however, are not the only age-associated neurodegenerative states where melatonin has been found to be protective.

Authors+Show Affiliations

Department of Cellular and Structural Biology, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. reiter@uthscsa.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18212398

Citation

Reiter, R J., et al. "Melatonin Defeats Neurally-derived Free Radicals and Reduces the Associated Neuromorphological and Neurobehavioral Damage." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 58 Suppl 6, 2007, pp. 5-22.
Reiter RJ, Tan DX, Manchester LC, et al. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J Physiol Pharmacol. 2007;58 Suppl 6:5-22.
Reiter, R. J., Tan, D. X., Manchester, L. C., & Tamura, H. (2007). Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 58 Suppl 6, pp. 5-22.
Reiter RJ, et al. Melatonin Defeats Neurally-derived Free Radicals and Reduces the Associated Neuromorphological and Neurobehavioral Damage. J Physiol Pharmacol. 2007;58 Suppl 6:5-22. PubMed PMID: 18212398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. AU - Reiter,R J, AU - Tan,D-X, AU - Manchester,L C, AU - Tamura,H, PY - 2007/09/12/received PY - 2007/11/14/accepted PY - 2008/3/28/pubmed PY - 2008/4/26/medline PY - 2008/3/28/entrez SP - 5 EP - 22 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J. Physiol. Pharmacol. VL - 58 Suppl 6 N2 - Melatonin and its metabolites are potent antioxidants by virtue of their ability to scavenge both oxygen-based and nitrogen-based radicals and intermediates but also as a consequence of their ability to stimulate the activity of antioxidative enzymes. Melatonin also prevents electron leakage from the mitochondrial electron transport chain thereby diminishing free radical generation; this process is referred to as radical avoidance. The fact that melatonin and its metabolites are all efficient radical scavengers indicates that melatonin is a precursor molecule for a variety of intracellular reducing agents. In specific reference to the brain, melatonin also has an advantage over some other antioxidants given that it readily passes through the blood-brain-barrier. This, coupled with the fact that it and its by-products are particularly efficient detoxifiers of reactive species, make these molecules of major importance in protecting the brain from oxidative/nitrosative abuse. This review summarizes the literature on two brain-related situations, i.e., traumatic brain and spinal cord injury and ischemia/reperfusion, and the neurodegenerative disease, amyotrophic lateral sclerosis, where melatonin has been shown to have efficacy in abating neural damage. These, however, are not the only age-associated neurodegenerative states where melatonin has been found to be protective. SN - 0867-5910 UR - https://www.unboundmedicine.com/medline/citation/18212398/Melatonin_defeats_neurally_derived_free_radicals_and_reduces_the_associated_neuromorphological_and_neurobehavioral_damage_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -