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Neuroprotection by oxygen in acute transient focal cerebral ischemia is dose dependent and shows superiority of hyperbaric oxygenation.
Cerebrovasc Dis. 2008; 25(3):193-201.CD

Abstract

The neuroprotective effect of oxygen after acute stroke in rats has been shown previously. However, the question of optimal dosing still remains unanswered. Thus, we investigated the use of oxygen at different concentrations by either normobaric oxygenation (NBO) or hyperbaric oxygenation (HBO) at different pressures in a model of transient ischemia/reperfusion in rats. Animals underwent 90 min of middle cerebral artery occlusion (MCAO) followed by 90 min of reperfusion before oxygen treatment. Oxygen was applied either by NBO (100% O(2); 1.0 absolute atmosphere, ATA) or HBO (100% O(2); 1.5, 2.0, 2.5 or 3.0 ATA) for 1 h. Primary endpoints were infarct volume and clinical outcome measured 24 h and 7 days following the MCAO. A statistically significant and long-lasting reduction in infarct volume was seen in the HBO 2.5 ATA and 3.0 ATA groups over a period of 7 days. The reduced infarct volume was accompanied with a statistically significant improvement in clinical outcome in the high-dose oxygen-treated groups. The presented data indicate that oxygen is a highly neuroprotective molecule in transient focal cerebral ischemia in rats, when applied early and at high doses. The effect is dose dependent and shows a superiority of HBO over NBO, when the primary endpoints infarct volume reduction and clinical outcome are analyzed. These data are important for the development of new acute stroke treatment studies in humans.

Authors+Show Affiliations

Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Germany. c.eschenfelder@neurologie.uni-kiel.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18212507

Citation

Eschenfelder, C C., et al. "Neuroprotection By Oxygen in Acute Transient Focal Cerebral Ischemia Is Dose Dependent and Shows Superiority of Hyperbaric Oxygenation." Cerebrovascular Diseases (Basel, Switzerland), vol. 25, no. 3, 2008, pp. 193-201.
Eschenfelder CC, Krug R, Yusofi AF, et al. Neuroprotection by oxygen in acute transient focal cerebral ischemia is dose dependent and shows superiority of hyperbaric oxygenation. Cerebrovasc Dis. 2008;25(3):193-201.
Eschenfelder, C. C., Krug, R., Yusofi, A. F., Meyne, J. K., Herdegen, T., Koch, A., Zhao, Y., Carl, U. M., & Deuschl, G. (2008). Neuroprotection by oxygen in acute transient focal cerebral ischemia is dose dependent and shows superiority of hyperbaric oxygenation. Cerebrovascular Diseases (Basel, Switzerland), 25(3), 193-201. https://doi.org/10.1159/000113856
Eschenfelder CC, et al. Neuroprotection By Oxygen in Acute Transient Focal Cerebral Ischemia Is Dose Dependent and Shows Superiority of Hyperbaric Oxygenation. Cerebrovasc Dis. 2008;25(3):193-201. PubMed PMID: 18212507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection by oxygen in acute transient focal cerebral ischemia is dose dependent and shows superiority of hyperbaric oxygenation. AU - Eschenfelder,C C, AU - Krug,R, AU - Yusofi,A F, AU - Meyne,J K, AU - Herdegen,T, AU - Koch,A, AU - Zhao,Y, AU - Carl,U M, AU - Deuschl,G, Y1 - 2008/01/23/ PY - 2007/06/12/received PY - 2007/09/21/accepted PY - 2008/1/24/pubmed PY - 2008/4/18/medline PY - 2008/1/24/entrez SP - 193 EP - 201 JF - Cerebrovascular diseases (Basel, Switzerland) JO - Cerebrovasc. Dis. VL - 25 IS - 3 N2 - The neuroprotective effect of oxygen after acute stroke in rats has been shown previously. However, the question of optimal dosing still remains unanswered. Thus, we investigated the use of oxygen at different concentrations by either normobaric oxygenation (NBO) or hyperbaric oxygenation (HBO) at different pressures in a model of transient ischemia/reperfusion in rats. Animals underwent 90 min of middle cerebral artery occlusion (MCAO) followed by 90 min of reperfusion before oxygen treatment. Oxygen was applied either by NBO (100% O(2); 1.0 absolute atmosphere, ATA) or HBO (100% O(2); 1.5, 2.0, 2.5 or 3.0 ATA) for 1 h. Primary endpoints were infarct volume and clinical outcome measured 24 h and 7 days following the MCAO. A statistically significant and long-lasting reduction in infarct volume was seen in the HBO 2.5 ATA and 3.0 ATA groups over a period of 7 days. The reduced infarct volume was accompanied with a statistically significant improvement in clinical outcome in the high-dose oxygen-treated groups. The presented data indicate that oxygen is a highly neuroprotective molecule in transient focal cerebral ischemia in rats, when applied early and at high doses. The effect is dose dependent and shows a superiority of HBO over NBO, when the primary endpoints infarct volume reduction and clinical outcome are analyzed. These data are important for the development of new acute stroke treatment studies in humans. SN - 1421-9786 UR - https://www.unboundmedicine.com/medline/citation/18212507/Neuroprotection_by_oxygen_in_acute_transient_focal_cerebral_ischemia_is_dose_dependent_and_shows_superiority_of_hyperbaric_oxygenation_ L2 - https://www.karger.com?DOI=10.1159/000113856 DB - PRIME DP - Unbound Medicine ER -