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Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease.
Nephron Clin Pract 2008; 108(2):c106-12NC

Abstract

BACKGROUND/AIMS

In end-stage renal disease (ESRD), hyperhomocysteinemia is a common finding associated with increased cardiovascular risk. However, the pathogenic role of homocysteine is still unclear. In vitro studies show that thiol redox status affects endothelial cell functions. We therefore investigated the possible association between homocysteinemia and plasma thiol redox status in ESRD patients.

METHODS

Total plasma homocysteine (Hcy), cysteine (Cys) and free thiols (SH) were measured both before and after a dialytic session in 54 ESRD patients receiving (n = 15) or not receiving (n = 39) folate supplementation, and 17 control subjects.

RESULTS

High predialysis levels of both Hcy and Cys were found to be negatively correlated with low SH levels both in supplemented (r = -0.680, p < 0.01 and r = -0.624, p < 0.02, respectively) and unsupplemented (r = -0.698, p < 0.001 and r = -0.445, p < 0.01, respectively) patients. Following dialysis, SH values returned to normal and the above correlations were no longer appreciable.

CONCLUSION

A strong, folate therapy-insensitive association between homocysteinemia and plasma free thiol levels was found in ESRD patients. These results support a role for oxidative stress in ESRD-related hyperhomocysteinemia and suggest the plasma thiol redox status alteration as a possible pathogenic mechanism underlying the cardiovascular toxicity of hyperhomocysteinemia in these patients.

Authors+Show Affiliations

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy. simonetta.palleschi@iss.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18212512

Citation

Palleschi, Simonetta, et al. "Homocysteinemia Correlates With Plasma Thiol Redox Status in Patients With End-stage Renal Disease." Nephron. Clinical Practice, vol. 108, no. 2, 2008, pp. c106-12.
Palleschi S, De Angelis S, Rossi B, et al. Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease. Nephron Clin Pract. 2008;108(2):c106-12.
Palleschi, S., De Angelis, S., Rossi, B., Diana, L., Papa, V., Severini, G., & Splendiani, G. (2008). Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease. Nephron. Clinical Practice, 108(2), pp. c106-12. doi:10.1159/000113527.
Palleschi S, et al. Homocysteinemia Correlates With Plasma Thiol Redox Status in Patients With End-stage Renal Disease. Nephron Clin Pract. 2008;108(2):c106-12. PubMed PMID: 18212512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteinemia correlates with plasma thiol redox status in patients with end-stage renal disease. AU - Palleschi,Simonetta, AU - De Angelis,Sandro, AU - Rossi,Barbara, AU - Diana,Loretta, AU - Papa,Vincenza, AU - Severini,Giancarlo, AU - Splendiani,Giorgio, Y1 - 2008/01/22/ PY - 2007/08/22/received PY - 2007/10/17/accepted PY - 2008/1/24/pubmed PY - 2008/2/22/medline PY - 2008/1/24/entrez SP - c106 EP - 12 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 108 IS - 2 N2 - BACKGROUND/AIMS: In end-stage renal disease (ESRD), hyperhomocysteinemia is a common finding associated with increased cardiovascular risk. However, the pathogenic role of homocysteine is still unclear. In vitro studies show that thiol redox status affects endothelial cell functions. We therefore investigated the possible association between homocysteinemia and plasma thiol redox status in ESRD patients. METHODS: Total plasma homocysteine (Hcy), cysteine (Cys) and free thiols (SH) were measured both before and after a dialytic session in 54 ESRD patients receiving (n = 15) or not receiving (n = 39) folate supplementation, and 17 control subjects. RESULTS: High predialysis levels of both Hcy and Cys were found to be negatively correlated with low SH levels both in supplemented (r = -0.680, p < 0.01 and r = -0.624, p < 0.02, respectively) and unsupplemented (r = -0.698, p < 0.001 and r = -0.445, p < 0.01, respectively) patients. Following dialysis, SH values returned to normal and the above correlations were no longer appreciable. CONCLUSION: A strong, folate therapy-insensitive association between homocysteinemia and plasma free thiol levels was found in ESRD patients. These results support a role for oxidative stress in ESRD-related hyperhomocysteinemia and suggest the plasma thiol redox status alteration as a possible pathogenic mechanism underlying the cardiovascular toxicity of hyperhomocysteinemia in these patients. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/18212512/Homocysteinemia_correlates_with_plasma_thiol_redox_status_in_patients_with_end_stage_renal_disease_ L2 - https://www.karger.com?DOI=10.1159/000113527 DB - PRIME DP - Unbound Medicine ER -