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Severity of carotid atherosclerosis unrelated to Chlamydia pneumoniae infection in acute ischemic stroke patients: a clinicopathological study.
Cerebrovasc Dis. 2008; 25(1-2):170-5.CD

Abstract

BACKGROUND

Both clinical and pathological alterations of the carotid arteries were correlated with Chlamydia pneumoniae infection in 67 acute ischemic stroke patients with severe neurological symptoms.

METHODS

In the clinical study, intima-media thickness (IMT) of the common carotid arteries was determined in vivo by B-mode ultrasound measurement and C. pneumoniae-specific IgG and IgA responses were detected. In the pathological study, the absolute wall thickness of the common, internal and external carotid arteries was measured postmortem in specimens obtained at the autopsy of patients who died due to complications of acute stroke. In the atherosclerotic plaques of the autopsy specimens, C. pneumoniae genomic DNA was detected by polymerase chain reaction amplification.

RESULTS

The Spearman's rho correlation coefficient of IMT with the average wall thickness of the common, internal and external carotid arteries was 0.51 (p = 0.002), 0.34 (p = 0.052) and 0.58 (p < 0.001), respectively. Anti-C. pneumoniae IgG and IgA antibodies were detected in 43 (73%) and 29 (49%) patients, but neither antibody marker correlated with IMT (median: 0.91 mm in IgG positives vs. 0.90 mm in IgG negatives, p = 0.86; 0.88 mm in IgA positives vs. 0.90 mm in IgA negatives, p = 0.53). The presence of C. pneumoniae DNA was detected in the carotid plaques of 21 (54%) of the 39 tested patients, independently of either IMT values or the average wall thickness of all carotid arteries.

CONCLUSIONS

In acute ischemic stroke patients, C. pneumoniae infection was frequently detected in the arteriosclerotic plaques of the carotid arteries but it did not correlate with the severity of carotid arteriosclerosis.

Authors+Show Affiliations

Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. konya@dote.huNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18212523

Citation

Kónya, József, et al. "Severity of Carotid Atherosclerosis Unrelated to Chlamydia Pneumoniae Infection in Acute Ischemic Stroke Patients: a Clinicopathological Study." Cerebrovascular Diseases (Basel, Switzerland), vol. 25, no. 1-2, 2008, pp. 170-5.
Kónya J, Molnár S, Magyar MT, et al. Severity of carotid atherosclerosis unrelated to Chlamydia pneumoniae infection in acute ischemic stroke patients: a clinicopathological study. Cerebrovasc Dis. 2008;25(1-2):170-5.
Kónya, J., Molnár, S., Magyar, M. T., Szekeres, C. C., Kerényi, L., & Csiba, L. (2008). Severity of carotid atherosclerosis unrelated to Chlamydia pneumoniae infection in acute ischemic stroke patients: a clinicopathological study. Cerebrovascular Diseases (Basel, Switzerland), 25(1-2), 170-5. https://doi.org/10.1159/000113735
Kónya J, et al. Severity of Carotid Atherosclerosis Unrelated to Chlamydia Pneumoniae Infection in Acute Ischemic Stroke Patients: a Clinicopathological Study. Cerebrovasc Dis. 2008;25(1-2):170-5. PubMed PMID: 18212523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severity of carotid atherosclerosis unrelated to Chlamydia pneumoniae infection in acute ischemic stroke patients: a clinicopathological study. AU - Kónya,József, AU - Molnár,Sándor, AU - Magyar,Mária T, AU - Szekeres,Csilla C, AU - Kerényi,Levente, AU - Csiba,László, Y1 - 2008/01/23/ PY - 2007/02/14/received PY - 2007/09/18/accepted PY - 2008/1/24/pubmed PY - 2008/4/11/medline PY - 2008/1/24/entrez SP - 170 EP - 5 JF - Cerebrovascular diseases (Basel, Switzerland) JO - Cerebrovasc Dis VL - 25 IS - 1-2 N2 - BACKGROUND: Both clinical and pathological alterations of the carotid arteries were correlated with Chlamydia pneumoniae infection in 67 acute ischemic stroke patients with severe neurological symptoms. METHODS: In the clinical study, intima-media thickness (IMT) of the common carotid arteries was determined in vivo by B-mode ultrasound measurement and C. pneumoniae-specific IgG and IgA responses were detected. In the pathological study, the absolute wall thickness of the common, internal and external carotid arteries was measured postmortem in specimens obtained at the autopsy of patients who died due to complications of acute stroke. In the atherosclerotic plaques of the autopsy specimens, C. pneumoniae genomic DNA was detected by polymerase chain reaction amplification. RESULTS: The Spearman's rho correlation coefficient of IMT with the average wall thickness of the common, internal and external carotid arteries was 0.51 (p = 0.002), 0.34 (p = 0.052) and 0.58 (p < 0.001), respectively. Anti-C. pneumoniae IgG and IgA antibodies were detected in 43 (73%) and 29 (49%) patients, but neither antibody marker correlated with IMT (median: 0.91 mm in IgG positives vs. 0.90 mm in IgG negatives, p = 0.86; 0.88 mm in IgA positives vs. 0.90 mm in IgA negatives, p = 0.53). The presence of C. pneumoniae DNA was detected in the carotid plaques of 21 (54%) of the 39 tested patients, independently of either IMT values or the average wall thickness of all carotid arteries. CONCLUSIONS: In acute ischemic stroke patients, C. pneumoniae infection was frequently detected in the arteriosclerotic plaques of the carotid arteries but it did not correlate with the severity of carotid arteriosclerosis. SN - 1421-9786 UR - https://www.unboundmedicine.com/medline/citation/18212523/Severity_of_carotid_atherosclerosis_unrelated_to_Chlamydia_pneumoniae_infection_in_acute_ischemic_stroke_patients:_a_clinicopathological_study_ L2 - https://www.karger.com?DOI=10.1159/000113735 DB - PRIME DP - Unbound Medicine ER -