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Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models.
Pharmazie. 2007 Dec; 62(12):919-24.P

Abstract

Serotonin type 3 (5-HT3) antagonists, which find an unflinching place in the management of nausea and emesis are presently screened for their neuro-pharmacological potential in various animal models. In the present study, 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile (NA-2) with an optimal log P and pA2 value comparable to that of ondansetron was screened in rodent models of depression. The acute and chronic (14 days) treatment of the synthetic compound exhibited antidepressant-like effects at the lower dose levels in mice forced swim test (FST). A typical and similar dose-immobility profile was observed in both mice FST and tail suspension test (TST). Interaction studies in FST revealed the reversal of mCPP induced immobility, attenuation of antidepressant effects of fluoxetine and desipramine. Chronic NA-2 treatment restored the behavioural deficits in olfactory bulbectomized (OBX) rats as indicated by reduction in hyperactivity in novel open field test. This preliminary study points to a serotonergic mechanism behind the antidepressant-like effects of NA-2 and invigorates further investigation of analogous compounds in various other models of depression.

Authors+Show Affiliations

Pharmacy Group, Birla Institute of Technology & Science, Pilani, Rajasthan, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18214343

Citation

Mahesh, R, et al. "Potential Antidepressants: Pharmacology of 2-(4-methyl Piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in Rodent Behavioural Models." Die Pharmazie, vol. 62, no. 12, 2007, pp. 919-24.
Mahesh R, Rajkumar R, Minasri B, et al. Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models. Pharmazie. 2007;62(12):919-24.
Mahesh, R., Rajkumar, R., Minasri, B., & Venkatesha Perumal, R. (2007). Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models. Die Pharmazie, 62(12), 919-24.
Mahesh R, et al. Potential Antidepressants: Pharmacology of 2-(4-methyl Piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in Rodent Behavioural Models. Pharmazie. 2007;62(12):919-24. PubMed PMID: 18214343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models. AU - Mahesh,R, AU - Rajkumar,R, AU - Minasri,B, AU - Venkatesha Perumal,R, PY - 2008/1/25/pubmed PY - 2008/3/5/medline PY - 2008/1/25/entrez SP - 919 EP - 24 JF - Die Pharmazie JO - Pharmazie VL - 62 IS - 12 N2 - Serotonin type 3 (5-HT3) antagonists, which find an unflinching place in the management of nausea and emesis are presently screened for their neuro-pharmacological potential in various animal models. In the present study, 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile (NA-2) with an optimal log P and pA2 value comparable to that of ondansetron was screened in rodent models of depression. The acute and chronic (14 days) treatment of the synthetic compound exhibited antidepressant-like effects at the lower dose levels in mice forced swim test (FST). A typical and similar dose-immobility profile was observed in both mice FST and tail suspension test (TST). Interaction studies in FST revealed the reversal of mCPP induced immobility, attenuation of antidepressant effects of fluoxetine and desipramine. Chronic NA-2 treatment restored the behavioural deficits in olfactory bulbectomized (OBX) rats as indicated by reduction in hyperactivity in novel open field test. This preliminary study points to a serotonergic mechanism behind the antidepressant-like effects of NA-2 and invigorates further investigation of analogous compounds in various other models of depression. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/18214343/Potential_antidepressants:_pharmacology_of_2__4_methyl_piperazin_1_yl__18_naphthyridine_3_carbonitrile_in_rodent_behavioural_models_ L2 - https://medlineplus.gov/antidepressants.html DB - PRIME DP - Unbound Medicine ER -