Tags

Type your tag names separated by a space and hit enter

An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry.
Rapid Commun Mass Spectrom. 2008; 22(4):526-32.RC

Abstract

Selected ion flow tube mass spectrometry (SIFT-MS) has been used to carry out a pilot parallel study on five volunteers to determine changes occurring in several trace compounds present in exhaled breath and emitted from skin into a collection bag surrounding part of the arm, before and after ingesting 75 g of glucose in the fasting state. SIFT-MS enabled real-time quantification of ammonia, methanol, ethanol, propanol, formaldehyde, acetaldehyde, isoprene and acetone. Following glucose ingestion, blood glucose and trace compound levels were measured every 30 min for 2 h. All the above compounds, except formaldehyde, were detected at the expected levels in exhaled breath of all volunteers; all the above compounds, except isoprene, were detected in the collection bag. Ammonia, methanol and ethanol were present at lower levels in the bag than in the breath. The aldehydes were present at higher levels in the bag than in breath. The blood glucose increased to a peak about 1 h post-ingestion, but this change was not obviously correlated with temporal changes in any of the compounds in breath or emitted by skin, except for acetone. The decrease in breath acetone was closely mirrored by skin-emitted acetone in three volunteers. Breath and skin acetone also clearly change with blood glucose and further work may ultimately enable inferences to be drawn of the blood glucose concentration from skin or breath measurements in type 1 diabetes.

Authors+Show Affiliations

Cranfield Health, Cranfield University, Silsoe, Bedford MK45 4DT, UK. c.turner@cranfield.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

18215004

Citation

Turner, Claire, et al. "An Exploratory Comparative Study of Volatile Compounds in Exhaled Breath and Emitted By Skin Using Selected Ion Flow Tube Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 22, no. 4, 2008, pp. 526-32.
Turner C, Parekh B, Walton C, et al. An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom. 2008;22(4):526-32.
Turner, C., Parekh, B., Walton, C., Spanel, P., Smith, D., & Evans, M. (2008). An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 22(4), 526-32. https://doi.org/10.1002/rcm.3402
Turner C, et al. An Exploratory Comparative Study of Volatile Compounds in Exhaled Breath and Emitted By Skin Using Selected Ion Flow Tube Mass Spectrometry. Rapid Commun Mass Spectrom. 2008;22(4):526-32. PubMed PMID: 18215004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An exploratory comparative study of volatile compounds in exhaled breath and emitted by skin using selected ion flow tube mass spectrometry. AU - Turner,Claire, AU - Parekh,Bhavin, AU - Walton,Christopher, AU - Spanel,Patrik, AU - Smith,David, AU - Evans,Mark, PY - 2008/1/25/pubmed PY - 2008/4/9/medline PY - 2008/1/25/entrez SP - 526 EP - 32 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 22 IS - 4 N2 - Selected ion flow tube mass spectrometry (SIFT-MS) has been used to carry out a pilot parallel study on five volunteers to determine changes occurring in several trace compounds present in exhaled breath and emitted from skin into a collection bag surrounding part of the arm, before and after ingesting 75 g of glucose in the fasting state. SIFT-MS enabled real-time quantification of ammonia, methanol, ethanol, propanol, formaldehyde, acetaldehyde, isoprene and acetone. Following glucose ingestion, blood glucose and trace compound levels were measured every 30 min for 2 h. All the above compounds, except formaldehyde, were detected at the expected levels in exhaled breath of all volunteers; all the above compounds, except isoprene, were detected in the collection bag. Ammonia, methanol and ethanol were present at lower levels in the bag than in the breath. The aldehydes were present at higher levels in the bag than in breath. The blood glucose increased to a peak about 1 h post-ingestion, but this change was not obviously correlated with temporal changes in any of the compounds in breath or emitted by skin, except for acetone. The decrease in breath acetone was closely mirrored by skin-emitted acetone in three volunteers. Breath and skin acetone also clearly change with blood glucose and further work may ultimately enable inferences to be drawn of the blood glucose concentration from skin or breath measurements in type 1 diabetes. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/18215004/An_exploratory_comparative_study_of_volatile_compounds_in_exhaled_breath_and_emitted_by_skin_using_selected_ion_flow_tube_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.3402 DB - PRIME DP - Unbound Medicine ER -