Tags

Type your tag names separated by a space and hit enter

Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects.
Ann Surg. 2008 Feb; 247(2):270-5.AnnS

Abstract

OBJECTIVE

To prospectively assess the relationship between circulating peptide YY (PYY), body weight, and glucose tolerance in severely obese subjects undergoing Roux-en-Y gastric bypass (RYGBP).

SUMMARY BACKGROUND DATA

The mechanisms accounting for the beneficial effects of RYGBP on body weight and glucose homeostasis are not well understood.

METHODS

Prospective study on the response of PYY to a standardized test meal (STM) and its relationship with weight loss and glucose homeostasis (fasting plasma glucose, HbA1c, HOMA-IR, HOMA-B) in nondiabetic (n = 25) and diabetic (n = 10) severely obese subjects evaluated before, and at 6 and 52 weeks after RYGBP.

RESULTS

The PYY response to a STM significantly increased (P < 0.001) already at 6 weeks at a time when subjects despite presenting a significant weight loss (-14.6% +/- 1.2%) were still markedly obese. Despite massive weight loss (-43.0% +/- 2.3%), no further increase in the area under the curve of PYY was observed at 52 weeks after surgery (P = 0.44). The PYY response to a STM at 6 weeks after surgery significantly correlated (r = 0.489, P < 0.05) with the percent excess weight loss at 32.5 +/- 1.1 months after surgery. In contrast, no significant correlation was found between PYY and glucose homeostasis parameters in nondiabetic and diabetic patients.

CONCLUSION

Our data support the hypothesis that an increased PYY response after meal ingestion is involved in the sustained weight loss observed after RYGBP. In contrast, our data does not support PYY being relevant in the changes in glucose homeostasis occurring after this type of bariatric surgery.

Authors+Show Affiliations

Obesity Unit, Hospital Clínic Universitari, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18216532

Citation

Morínigo, Rosa, et al. "Circulating Peptide YY, Weight Loss, and Glucose Homeostasis After Gastric Bypass Surgery in Morbidly Obese Subjects." Annals of Surgery, vol. 247, no. 2, 2008, pp. 270-5.
Morínigo R, Vidal J, Lacy AM, et al. Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. Ann Surg. 2008;247(2):270-5.
Morínigo, R., Vidal, J., Lacy, A. M., Delgado, S., Casamitjana, R., & Gomis, R. (2008). Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. Annals of Surgery, 247(2), 270-5. https://doi.org/10.1097/SLA.0b013e31815f6e77
Morínigo R, et al. Circulating Peptide YY, Weight Loss, and Glucose Homeostasis After Gastric Bypass Surgery in Morbidly Obese Subjects. Ann Surg. 2008;247(2):270-5. PubMed PMID: 18216532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. AU - Morínigo,Rosa, AU - Vidal,Josep, AU - Lacy,Antonio M, AU - Delgado,Salvadora, AU - Casamitjana,Roser, AU - Gomis,Ramon, PY - 2008/1/25/pubmed PY - 2008/3/14/medline PY - 2008/1/25/entrez SP - 270 EP - 5 JF - Annals of surgery JO - Ann Surg VL - 247 IS - 2 N2 - OBJECTIVE: To prospectively assess the relationship between circulating peptide YY (PYY), body weight, and glucose tolerance in severely obese subjects undergoing Roux-en-Y gastric bypass (RYGBP). SUMMARY BACKGROUND DATA: The mechanisms accounting for the beneficial effects of RYGBP on body weight and glucose homeostasis are not well understood. METHODS: Prospective study on the response of PYY to a standardized test meal (STM) and its relationship with weight loss and glucose homeostasis (fasting plasma glucose, HbA1c, HOMA-IR, HOMA-B) in nondiabetic (n = 25) and diabetic (n = 10) severely obese subjects evaluated before, and at 6 and 52 weeks after RYGBP. RESULTS: The PYY response to a STM significantly increased (P < 0.001) already at 6 weeks at a time when subjects despite presenting a significant weight loss (-14.6% +/- 1.2%) were still markedly obese. Despite massive weight loss (-43.0% +/- 2.3%), no further increase in the area under the curve of PYY was observed at 52 weeks after surgery (P = 0.44). The PYY response to a STM at 6 weeks after surgery significantly correlated (r = 0.489, P < 0.05) with the percent excess weight loss at 32.5 +/- 1.1 months after surgery. In contrast, no significant correlation was found between PYY and glucose homeostasis parameters in nondiabetic and diabetic patients. CONCLUSION: Our data support the hypothesis that an increased PYY response after meal ingestion is involved in the sustained weight loss observed after RYGBP. In contrast, our data does not support PYY being relevant in the changes in glucose homeostasis occurring after this type of bariatric surgery. SN - 0003-4932 UR - https://www.unboundmedicine.com/medline/citation/18216532/Circulating_peptide_YY_weight_loss_and_glucose_homeostasis_after_gastric_bypass_surgery_in_morbidly_obese_subjects_ L2 - https://Insights.ovid.com/pubmed?pmid=18216532 DB - PRIME DP - Unbound Medicine ER -