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Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease.
Curr Opin Neurobiol. 1991 Oct; 1(3):441-7.CO

Abstract

Alzheimer's disease is characterized by the presence of abundant neurofibrillary tangles and beta-amyloid deposits in neocortex, hippocampus and amygdala. The major protein components of tangles and plaques have recently been identified. These findings, briefly reviewed here, will allow researchers to design investigations that will lead to an understanding of the pathogenesis of the disease and to the development of new therapeutic approaches that may result in an effective treatment.

Authors+Show Affiliations

Goedert M
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
Sisodia SS
No affiliation info available
Price DL
No affiliation info available

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainHumansNeurofibrillary Tanglestau Proteins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

1821689

Citation

Goedert, M, et al. "Neurofibrillary Tangles and Beta-amyloid Deposits in Alzheimer's Disease." Current Opinion in Neurobiology, vol. 1, no. 3, 1991, pp. 441-7.
Goedert M, Sisodia SS, Price DL. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Curr Opin Neurobiol. 1991;1(3):441-7.
Goedert, M., Sisodia, S. S., & Price, D. L. (1991). Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Current Opinion in Neurobiology, 1(3), 441-7.
Goedert M, Sisodia SS, Price DL. Neurofibrillary Tangles and Beta-amyloid Deposits in Alzheimer's Disease. Curr Opin Neurobiol. 1991;1(3):441-7. PubMed PMID: 1821689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. AU - Goedert,M, AU - Sisodia,S S, AU - Price,D L, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 441 EP - 7 JF - Current opinion in neurobiology JO - Curr Opin Neurobiol VL - 1 IS - 3 N2 - Alzheimer's disease is characterized by the presence of abundant neurofibrillary tangles and beta-amyloid deposits in neocortex, hippocampus and amygdala. The major protein components of tangles and plaques have recently been identified. These findings, briefly reviewed here, will allow researchers to design investigations that will lead to an understanding of the pathogenesis of the disease and to the development of new therapeutic approaches that may result in an effective treatment. SN - 0959-4388 UR - https://www.unboundmedicine.com/medline/citation/1821689/Neurofibrillary_tangles_and_beta_amyloid_deposits_in_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -