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Effects of stress on emotional reactivity in hostile heavy social drinkers following dietary tryptophan enhancement.
Alcohol Alcohol. 2008 Mar-Apr; 43(2):151-62.AA

Abstract

AIM

Because individuals high on hostility may be at risk for alcohol abuse due to serotonergic dysfunction and greater reactivity to stress, we examined the effects of acute dietary tryptophan enhancement and stress on mood and craving for alcohol in low-hostile (LoH) and high-hostile (HiH) individuals.

METHODS

Thirty-four LoH and 33 HiH heavy social drinkers [selection based on the Hostility scale from the Buss and Perry Aggression Questionnaire (1992)] received either tryptophan-enriched or control diet and underwent a stress-induction procedure. Trait differences between the two hostile groups were explored using personality, anxiety, and depression questionnaires. Mood, craving for alcohol, and salivary cortisol levels (CORT) were measured before and after tryptophan and after stress-induction. Heart rate (HR) was measured during stress-induction.

RESULTS

HiHs compared to LoHs scored higher on the depression and anxiety trait scales as well in the character dimension Harm Avoidance and reported more of stress exposure over the past month. They also showed more negative mood and higher craving for alcohol. Diet alone did not produce any subjective or physiological effects. Stress increased CORT, HR, negative mood, and craving for alcohol. HiHs displayed higher CORT increase and lower cardiovascular reactivity in response to stress compared to LoHs. Opposite to the predictions, tryptophan enhancement selectively facilitated stress-induced increase in craving in the HiHs.

CONCLUSION

Among heavy drinkers HiHs report higher craving for alcohol and show greater reactivity to stress as measured by CORT and negative mood. The effects of stress on craving in HiHs may be mediated by a serotonergic mechanism.

Authors+Show Affiliations

Department of Psychology, University of Sussex, Falmer, Brighton, UK.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18218724

Citation

Nesic, J, and T Duka. "Effects of Stress On Emotional Reactivity in Hostile Heavy Social Drinkers Following Dietary Tryptophan Enhancement." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 43, no. 2, 2008, pp. 151-62.
Nesic J, Duka T. Effects of stress on emotional reactivity in hostile heavy social drinkers following dietary tryptophan enhancement. Alcohol Alcohol. 2008;43(2):151-62.
Nesic, J., & Duka, T. (2008). Effects of stress on emotional reactivity in hostile heavy social drinkers following dietary tryptophan enhancement. Alcohol and Alcoholism (Oxford, Oxfordshire), 43(2), 151-62. https://doi.org/10.1093/alcalc/agm179
Nesic J, Duka T. Effects of Stress On Emotional Reactivity in Hostile Heavy Social Drinkers Following Dietary Tryptophan Enhancement. Alcohol Alcohol. 2008 Mar-Apr;43(2):151-62. PubMed PMID: 18218724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of stress on emotional reactivity in hostile heavy social drinkers following dietary tryptophan enhancement. AU - Nesic,J, AU - Duka,T, Y1 - 2008/01/24/ PY - 2008/1/26/pubmed PY - 2008/5/9/medline PY - 2008/1/26/entrez SP - 151 EP - 62 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 43 IS - 2 N2 - AIM: Because individuals high on hostility may be at risk for alcohol abuse due to serotonergic dysfunction and greater reactivity to stress, we examined the effects of acute dietary tryptophan enhancement and stress on mood and craving for alcohol in low-hostile (LoH) and high-hostile (HiH) individuals. METHODS: Thirty-four LoH and 33 HiH heavy social drinkers [selection based on the Hostility scale from the Buss and Perry Aggression Questionnaire (1992)] received either tryptophan-enriched or control diet and underwent a stress-induction procedure. Trait differences between the two hostile groups were explored using personality, anxiety, and depression questionnaires. Mood, craving for alcohol, and salivary cortisol levels (CORT) were measured before and after tryptophan and after stress-induction. Heart rate (HR) was measured during stress-induction. RESULTS: HiHs compared to LoHs scored higher on the depression and anxiety trait scales as well in the character dimension Harm Avoidance and reported more of stress exposure over the past month. They also showed more negative mood and higher craving for alcohol. Diet alone did not produce any subjective or physiological effects. Stress increased CORT, HR, negative mood, and craving for alcohol. HiHs displayed higher CORT increase and lower cardiovascular reactivity in response to stress compared to LoHs. Opposite to the predictions, tryptophan enhancement selectively facilitated stress-induced increase in craving in the HiHs. CONCLUSION: Among heavy drinkers HiHs report higher craving for alcohol and show greater reactivity to stress as measured by CORT and negative mood. The effects of stress on craving in HiHs may be mediated by a serotonergic mechanism. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/18218724/Effects_of_stress_on_emotional_reactivity_in_hostile_heavy_social_drinkers_following_dietary_tryptophan_enhancement_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agm179 DB - PRIME DP - Unbound Medicine ER -