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[Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)].
Med Klin (Munich). 2008 Jan 15; 103(1):29-35.MK

Abstract

BACKGROUND

Visceral leishmaniasis is a rare imported infectious disease in Germany. Approximately ten to 30 cases are recorded annually. The classic symptoms are often misinterpreted as lymphoma of the spleen.

CASE REPORT

A 46-year-old patient presented with fever, malaise, night sweats, pancytopenia, and splenomegaly 8 months after a 2-week trip to Majorca Island (Spain). Bone marrow biopsy showed no evidence of malignant lymphoma. Serology confirmed the suspected clinical diagnosis of visceral leishmaniasis. Cytology and polymerase chain reaction from bone marrow aspirate were positive for Leishmania infantum. Treatment with liposomal amphotericin B was initiated and led to complete recovery.

CONCLUSION

Visceral leishmaniasis is an important differential diagnosis for the clinical triad of fever, pancytopenia, and splenomegaly. An accurate travel history is therefore of paramount importance. Without treatment, the case fatality rate is high. A complete recovery is usually achieved with adequate therapy (liposomal amphotericin B, miltefosine).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lübbert C
Klinik und Poliklinik für Innere Medizin I, Klinikum der Martin-Luther-Universität Halle-Wittenberg, Halle-Wittenberg. christoph.luebbert@medizin.uni-halle.de
Opitz BM
No affiliation info available
Harms-Zwingenberger G
No affiliation info available
Nietsch HH
No affiliation info available

MeSH

Amphotericin BAnimalsAntiprotozoal AgentsDiagnosis, DifferentialFeverLeishmania infantumLeishmaniasis, VisceralLiposomesMaleMediterranean IslandsPancytopeniaPolymerase Chain ReactionSpainSplenomegalyTravelTreatment Outcome

Pub Type(s)

Case Reports
Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

18219460

Citation

Lübbert, Christoph, et al. "[Fever, Pancytopenia, and Splenomegaly 8 Months After a Trip to Majorca Island (Spain)]." Medizinische Klinik (Munich, Germany : 1983), vol. 103, no. 1, 2008, pp. 29-35.
Lübbert C, Opitz BM, Harms-Zwingenberger G, et al. [Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)]. Med Klin (Munich). 2008;103(1):29-35.
Lübbert, C., Opitz, B. M., Harms-Zwingenberger, G., & Nietsch, H. H. (2008). [Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)]. Medizinische Klinik (Munich, Germany : 1983), 103(1), 29-35. https://doi.org/10.1007/s00063-008-1003-5
Lübbert C, et al. [Fever, Pancytopenia, and Splenomegaly 8 Months After a Trip to Majorca Island (Spain)]. Med Klin (Munich). 2008 Jan 15;103(1):29-35. PubMed PMID: 18219460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fever, pancytopenia, and splenomegaly 8 months after a trip to Majorca Island (Spain)]. AU - Lübbert,Christoph, AU - Opitz,Bernhard M, AU - Harms-Zwingenberger,Gundel, AU - Nietsch,Hubertus H, PY - 2007/09/14/received PY - 2007/11/12/accepted PY - 2008/1/26/pubmed PY - 2008/4/19/medline PY - 2008/1/26/entrez SP - 29 EP - 35 JF - Medizinische Klinik (Munich, Germany : 1983) JO - Med Klin (Munich) VL - 103 IS - 1 N2 - BACKGROUND: Visceral leishmaniasis is a rare imported infectious disease in Germany. Approximately ten to 30 cases are recorded annually. The classic symptoms are often misinterpreted as lymphoma of the spleen. CASE REPORT: A 46-year-old patient presented with fever, malaise, night sweats, pancytopenia, and splenomegaly 8 months after a 2-week trip to Majorca Island (Spain). Bone marrow biopsy showed no evidence of malignant lymphoma. Serology confirmed the suspected clinical diagnosis of visceral leishmaniasis. Cytology and polymerase chain reaction from bone marrow aspirate were positive for Leishmania infantum. Treatment with liposomal amphotericin B was initiated and led to complete recovery. CONCLUSION: Visceral leishmaniasis is an important differential diagnosis for the clinical triad of fever, pancytopenia, and splenomegaly. An accurate travel history is therefore of paramount importance. Without treatment, the case fatality rate is high. A complete recovery is usually achieved with adequate therapy (liposomal amphotericin B, miltefosine). SN - 0723-5003 UR - https://www.unboundmedicine.com/medline/citation/18219460/[Fever_pancytopenia_and_splenomegaly_8_months_after_a_trip_to_Majorca_Island__Spain_]_ DB - PRIME DP - Unbound Medicine ER -