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Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues.
J Magn Reson Imaging. 2008 Mar; 27(3):552-6.JM

Abstract

PURPOSE

To identify age-related changes and differences in the diffusion of water molecules within the prostate, through diffusion-weighted imaging (DWI) of the prostate gland in healthy adult Japanese men.

MATERIALS AND METHODS

A total of 114 healthy male volunteers (mean age, 55 years; range, 24-81 years) underwent DWI of the prostate with a single-shot echo-planar imaging (EPI) sequence using b-factors of 0 and 1000 seconds/mm(2). Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined.

RESULTS

ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 +/- 0.27 x 10(-3) mm(2)/second for PZ and 1.26 +/- 0.12 x 10(-3) mm(2)/second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, P < 0.0001; r = 0.190, P = 0.0431, respectively).

CONCLUSION

ADC values within both PZ and CG regions of the prostate increase with age, and this must be taken into consideration when using DWI in the diagnosis of prostate cancer.

Authors+Show Affiliations

Department of Radiology, Kawasaki, Medical School, Okayama, Japan. ttamada@med.kawasaki-m.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18219616

Citation

Tamada, Tsutomu, et al. "Age-related and Zonal Anatomical Changes of Apparent Diffusion Coefficient Values in Normal Human Prostatic Tissues." Journal of Magnetic Resonance Imaging : JMRI, vol. 27, no. 3, 2008, pp. 552-6.
Tamada T, Sone T, Toshimitsu S, et al. Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues. J Magn Reson Imaging. 2008;27(3):552-6.
Tamada, T., Sone, T., Toshimitsu, S., Imai, S., Jo, Y., Yoshida, K., Yamamoto, A., Yamashita, T., Egashira, N., Nagai, K., & Fukunaga, M. (2008). Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues. Journal of Magnetic Resonance Imaging : JMRI, 27(3), 552-6. https://doi.org/10.1002/jmri.21117
Tamada T, et al. Age-related and Zonal Anatomical Changes of Apparent Diffusion Coefficient Values in Normal Human Prostatic Tissues. J Magn Reson Imaging. 2008;27(3):552-6. PubMed PMID: 18219616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related and zonal anatomical changes of apparent diffusion coefficient values in normal human prostatic tissues. AU - Tamada,Tsutomu, AU - Sone,Teruki, AU - Toshimitsu,Shinya, AU - Imai,Shigeki, AU - Jo,Yoshimasa, AU - Yoshida,Koji, AU - Yamamoto,Akira, AU - Yamashita,Takenori, AU - Egashira,Naoto, AU - Nagai,Kiyohisa, AU - Fukunaga,Masao, PY - 2008/1/26/pubmed PY - 2008/6/28/medline PY - 2008/1/26/entrez SP - 552 EP - 6 JF - Journal of magnetic resonance imaging : JMRI JO - J Magn Reson Imaging VL - 27 IS - 3 N2 - PURPOSE: To identify age-related changes and differences in the diffusion of water molecules within the prostate, through diffusion-weighted imaging (DWI) of the prostate gland in healthy adult Japanese men. MATERIALS AND METHODS: A total of 114 healthy male volunteers (mean age, 55 years; range, 24-81 years) underwent DWI of the prostate with a single-shot echo-planar imaging (EPI) sequence using b-factors of 0 and 1000 seconds/mm(2). Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined. RESULTS: ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 +/- 0.27 x 10(-3) mm(2)/second for PZ and 1.26 +/- 0.12 x 10(-3) mm(2)/second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, P < 0.0001; r = 0.190, P = 0.0431, respectively). CONCLUSION: ADC values within both PZ and CG regions of the prostate increase with age, and this must be taken into consideration when using DWI in the diagnosis of prostate cancer. SN - 1053-1807 UR - https://www.unboundmedicine.com/medline/citation/18219616/Age_related_and_zonal_anatomical_changes_of_apparent_diffusion_coefficient_values_in_normal_human_prostatic_tissues_ L2 - https://doi.org/10.1002/jmri.21117 DB - PRIME DP - Unbound Medicine ER -