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A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma.
Eur J Cancer 2008; 44(3):465-71EJ

Abstract

The incidence of oesophageal adenocarcinoma (EADC) is rapidly increasing in Western countries and obesity is thought to be a major risk factor. We examined the association between BMI and EADC, gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma in a cohort of approximately 500,000 people in the United States (US). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) with control for many potential confounders. We found that compared to people with a BMI of 18.5-25kg/m2, a BMI > or = 35 was associated with significantly increased risk of EADC, HR (95% CI)=2.27 (1.44-3.59) and gastric cardia adenocarcinoma 2.46 (1.60-3.80), but not gastric non-cardia adenocarcinoma 0.84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, United States. abnetc@mail.nih.gov

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

18221867

Citation

Abnet, Christian C., et al. "A Prospective Study of BMI and Risk of Oesophageal and Gastric Adenocarcinoma." European Journal of Cancer (Oxford, England : 1990), vol. 44, no. 3, 2008, pp. 465-71.
Abnet CC, Freedman ND, Hollenbeck AR, et al. A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur J Cancer. 2008;44(3):465-71.
Abnet, C. C., Freedman, N. D., Hollenbeck, A. R., Fraumeni, J. F., Leitzmann, M., & Schatzkin, A. (2008). A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. European Journal of Cancer (Oxford, England : 1990), 44(3), pp. 465-71. doi:10.1016/j.ejca.2007.12.009.
Abnet CC, et al. A Prospective Study of BMI and Risk of Oesophageal and Gastric Adenocarcinoma. Eur J Cancer. 2008;44(3):465-71. PubMed PMID: 18221867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. AU - Abnet,Christian C, AU - Freedman,Neal D, AU - Hollenbeck,Albert R, AU - Fraumeni,Joseph F,Jr AU - Leitzmann,Michael, AU - Schatzkin,Arthur, Y1 - 2008/01/24/ PY - 2007/11/23/received PY - 2007/12/10/accepted PY - 2008/1/29/pubmed PY - 2008/5/16/medline PY - 2008/1/29/entrez SP - 465 EP - 71 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 44 IS - 3 N2 - The incidence of oesophageal adenocarcinoma (EADC) is rapidly increasing in Western countries and obesity is thought to be a major risk factor. We examined the association between BMI and EADC, gastric cardia adenocarcinoma and gastric non-cardia adenocarcinoma in a cohort of approximately 500,000 people in the United States (US). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) with control for many potential confounders. We found that compared to people with a BMI of 18.5-25kg/m2, a BMI > or = 35 was associated with significantly increased risk of EADC, HR (95% CI)=2.27 (1.44-3.59) and gastric cardia adenocarcinoma 2.46 (1.60-3.80), but not gastric non-cardia adenocarcinoma 0.84 (0.50-1.42). Using non-linear models, we found that higher BMI was associated with increased risk of EADC even within the normal BMI. Increased adiposity was associated with higher risk of EADC even within the normal weight range. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/18221867/A_prospective_study_of_BMI_and_risk_of_oesophageal_and_gastric_adenocarcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(07)00987-2 DB - PRIME DP - Unbound Medicine ER -