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Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study.
Am J Obstet Gynecol. 2008 Mar; 198(3):279.e1-8.AJ

Abstract

OBJECTIVE

The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms.

STUDY DESIGN

This was a population-based prospective cohort study.

RESULTS

An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94).

CONCLUSION

Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms.

Authors+Show Affiliations

Division of Research, Kaiser Permanente, Oakland, CA 94612, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18221932

Citation

Weng, Xiaoping, et al. "Maternal Caffeine Consumption During Pregnancy and the Risk of Miscarriage: a Prospective Cohort Study." American Journal of Obstetrics and Gynecology, vol. 198, no. 3, 2008, pp. 279.e1-8.
Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol. 2008;198(3):279.e1-8.
Weng, X., Odouli, R., & Li, D. K. (2008). Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. American Journal of Obstetrics and Gynecology, 198(3), e1-8. https://doi.org/10.1016/j.ajog.2007.10.803
Weng X, Odouli R, Li DK. Maternal Caffeine Consumption During Pregnancy and the Risk of Miscarriage: a Prospective Cohort Study. Am J Obstet Gynecol. 2008;198(3):279.e1-8. PubMed PMID: 18221932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. AU - Weng,Xiaoping, AU - Odouli,Roxana, AU - Li,De-Kun, Y1 - 2008/01/25/ PY - 2007/04/02/received PY - 2007/07/20/revised PY - 2007/10/13/accepted PY - 2008/1/29/pubmed PY - 2008/4/9/medline PY - 2008/1/29/entrez SP - 279.e1 EP - 8 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 198 IS - 3 N2 - OBJECTIVE: The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. STUDY DESIGN: This was a population-based prospective cohort study. RESULTS: An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to 2.15) for caffeine intake of less than 200 mg/day, and aHR of 2.23 (1.34 to 3.69) for intake of 200 or more mg/day, respectively. Nausea or vomiting during pregnancy did not materially affect this observed association, nor did the change in intake pattern of caffeine during pregnancy. In addition, the magnitude of the association appeared to be stronger among women without a history of miscarriage (aHR 2.33, 1.48 to 3.67) than that among women with such a history (aHR 0.81, 0.34 to 1.94). CONCLUSION: Our results demonstrated that high doses of caffeine intake during pregnancy increase the risk of miscarriage, independent of pregnancy-related symptoms. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/18221932/Maternal_caffeine_consumption_during_pregnancy_and_the_risk_of_miscarriage:_a_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(07)02025-X DB - PRIME DP - Unbound Medicine ER -