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Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study.

Abstract

PURPOSE

To assess the association of cardiovascular risk factors and ocular perfusion pressure with early and advanced age-related macular degeneration (AMD) in Latinos.

DESIGN

Population-based, cross-sectional study.

METHODS

Data were collected from a population-based sample of self-identified adult Latinos using standardized protocols for assessing blood pressure and intraocular pressure (IOP) measurement and stereoscopic macular photography. Hypertension was defined as either a history of hypertension or systolic blood pressure (SBP) > 140 mm Hg +/- diastolic blood pressure (DBP) > or = 85 mm Hg. Ocular perfusion pressure (OPP) was defined as the difference between mean arterial blood pressure and IOP. AMD was diagnosed from photographic grading by masked trained graders. Logistic regression was used to assess associations.

RESULTS

Gradable retinal photographs were available in 5,875 participants. After adjusting for age, gender, and cigarette smoking, higher DBP and uncontrolled diastolic hypertension were associated with exudative AMD (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1 to 2.8; and OR, 3.3; CI, 1.2 to 9.3, respectively). Higher OPP was associated with a decreased risk of geographic atrophy (GA) (OR, 0.4 per 10 mm Hg; CI, 0.3 to 0.5). Low pulse pressure was associated with a lower risk of exudative AMD (OR, 0.2; CI, 0.1 to 0.6). Obesity was associated with increased retinal pigment (OR, 1.6; CI, 1.0 to 2.3).

CONCLUSIONS

These data suggest that in Latinos cardiovascular risk factors may play a role in advanced AMD. Given that Latinos have a high prevalence of cardiovascular risk factors, an intervention aimed at reducing these risk factors may also have a beneficial impact on the risk of having early and advanced AMD.

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  • Authors+Show Affiliations

    ,

    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

    , , , , ,

    Source

    American journal of ophthalmology 145:2 2008 Feb pg 308-16

    MeSH

    Blood Pressure
    Body Mass Index
    Cardiovascular Diseases
    Cross-Sectional Studies
    Diabetes Complications
    Female
    Hispanic Americans
    Humans
    Hypertension
    Intraocular Pressure
    Los Angeles
    Macular Degeneration
    Male
    Middle Aged
    Odds Ratio
    Prevalence
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18222193

    Citation

    Fraser-Bell, Samantha, et al. "Cardiovascular Risk Factors and Age-related Macular Degeneration: the Los Angeles Latino Eye Study." American Journal of Ophthalmology, vol. 145, no. 2, 2008, pp. 308-16.
    Fraser-Bell S, Wu J, Klein R, et al. Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2008;145(2):308-16.
    Fraser-Bell, S., Wu, J., Klein, R., Azen, S. P., Hooper, C., Foong, A. W., & Varma, R. (2008). Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study. American Journal of Ophthalmology, 145(2), pp. 308-16. doi:10.1016/j.ajo.2007.10.007.
    Fraser-Bell S, et al. Cardiovascular Risk Factors and Age-related Macular Degeneration: the Los Angeles Latino Eye Study. Am J Ophthalmol. 2008;145(2):308-16. PubMed PMID: 18222193.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study. AU - Fraser-Bell,Samantha, AU - Wu,Joanne, AU - Klein,Ronald, AU - Azen,Stanley P, AU - Hooper,Claire, AU - Foong,Athena W P, AU - Varma,Rohit, PY - 2007/07/03/received PY - 2007/10/01/revised PY - 2007/10/08/accepted PY - 2008/1/29/pubmed PY - 2008/3/21/medline PY - 2008/1/29/entrez SP - 308 EP - 16 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 145 IS - 2 N2 - PURPOSE: To assess the association of cardiovascular risk factors and ocular perfusion pressure with early and advanced age-related macular degeneration (AMD) in Latinos. DESIGN: Population-based, cross-sectional study. METHODS: Data were collected from a population-based sample of self-identified adult Latinos using standardized protocols for assessing blood pressure and intraocular pressure (IOP) measurement and stereoscopic macular photography. Hypertension was defined as either a history of hypertension or systolic blood pressure (SBP) > 140 mm Hg +/- diastolic blood pressure (DBP) > or = 85 mm Hg. Ocular perfusion pressure (OPP) was defined as the difference between mean arterial blood pressure and IOP. AMD was diagnosed from photographic grading by masked trained graders. Logistic regression was used to assess associations. RESULTS: Gradable retinal photographs were available in 5,875 participants. After adjusting for age, gender, and cigarette smoking, higher DBP and uncontrolled diastolic hypertension were associated with exudative AMD (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1 to 2.8; and OR, 3.3; CI, 1.2 to 9.3, respectively). Higher OPP was associated with a decreased risk of geographic atrophy (GA) (OR, 0.4 per 10 mm Hg; CI, 0.3 to 0.5). Low pulse pressure was associated with a lower risk of exudative AMD (OR, 0.2; CI, 0.1 to 0.6). Obesity was associated with increased retinal pigment (OR, 1.6; CI, 1.0 to 2.3). CONCLUSIONS: These data suggest that in Latinos cardiovascular risk factors may play a role in advanced AMD. Given that Latinos have a high prevalence of cardiovascular risk factors, an intervention aimed at reducing these risk factors may also have a beneficial impact on the risk of having early and advanced AMD. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/18222193/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(07)00884-7 DB - PRIME DP - Unbound Medicine ER -