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Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model.
Exp Biol Med (Maywood). 2008 Feb; 233(2):192-9.EB

Abstract

In this study, we investigated the effect of the methanol extract of fruits of Vitis amurensis Rupr. (Vitaceae; MEVA) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases, such as asthma and sinusitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. MEVA inhibited compound 48/80-induced systemic reactions and serum histamine release in a dose-dependent manner in mice. MEVA decreased immunoglobulin E (IgE)-mediated local allergic reactions, passive cutaneous anaphylaxis. MEVA dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. The inhibitory effect of MEVA on histamine release was mediated by the modulation of intracellular calcium. In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. The inhibitory effect of MEVA on these proinflammatory cytokines was p38 mitogen-activated protein kinase and nuclear factor-kappaB (NF-kappaB) dependent. Our findings provide evidence that MEVA inhibits mast cell-derived, immediate-type allergic reactions and involvement of proinflammatory cytokines, p38 MAPK, and NF-kappaB in these effects.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18222974

Citation

Kim, Sang-Hyun, et al. "Antiallergic Effects of Vitis Amurensis On Mast Cell-mediated Allergy Model." Experimental Biology and Medicine (Maywood, N.J.), vol. 233, no. 2, 2008, pp. 192-9.
Kim SH, Kwon TK, Shin TY. Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model. Exp Biol Med (Maywood). 2008;233(2):192-9.
Kim, S. H., Kwon, T. K., & Shin, T. Y. (2008). Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model. Experimental Biology and Medicine (Maywood, N.J.), 233(2), 192-9. https://doi.org/10.3181/0708-RM-222
Kim SH, Kwon TK, Shin TY. Antiallergic Effects of Vitis Amurensis On Mast Cell-mediated Allergy Model. Exp Biol Med (Maywood). 2008;233(2):192-9. PubMed PMID: 18222974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiallergic effects of Vitis amurensis on mast cell-mediated allergy model. AU - Kim,Sang-Hyun, AU - Kwon,Taeg Kyu, AU - Shin,Tae-Yong, PY - 2008/1/29/pubmed PY - 2008/3/15/medline PY - 2008/1/29/entrez SP - 192 EP - 9 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp Biol Med (Maywood) VL - 233 IS - 2 N2 - In this study, we investigated the effect of the methanol extract of fruits of Vitis amurensis Rupr. (Vitaceae; MEVA) on the mast cell-mediated allergy model and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases, such as asthma and sinusitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. MEVA inhibited compound 48/80-induced systemic reactions and serum histamine release in a dose-dependent manner in mice. MEVA decreased immunoglobulin E (IgE)-mediated local allergic reactions, passive cutaneous anaphylaxis. MEVA dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. The inhibitory effect of MEVA on histamine release was mediated by the modulation of intracellular calcium. In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. The inhibitory effect of MEVA on these proinflammatory cytokines was p38 mitogen-activated protein kinase and nuclear factor-kappaB (NF-kappaB) dependent. Our findings provide evidence that MEVA inhibits mast cell-derived, immediate-type allergic reactions and involvement of proinflammatory cytokines, p38 MAPK, and NF-kappaB in these effects. SN - 1535-3702 UR - https://www.unboundmedicine.com/medline/citation/18222974/Antiallergic_effects_of_Vitis_amurensis_on_mast_cell_mediated_allergy_model_ L2 - https://journals.sagepub.com/doi/10.3181/0708-RM-222?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -