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BMI and health status among adults with asthma.
Obesity (Silver Spring) 2008; 16(1):146-52O

Abstract

BACKGROUND

A convincing body of literature links obesity with a higher risk for developing adult-onset asthma. The impact of obesity on asthma severity among adults with pre-existing asthma, however, is less clear.

METHODS AND PROCEDURES

In a prospective cohort study of 843 adults with severe asthma, we studied the impact of BMI on asthma health status.

RESULTS

The prevalence of obesity and overweight were 44% (95% confidence interval (CI) 41-47%) and 28% (95% CI 25-32%). The obese BMI group was associated with a higher risk for daily or near daily asthma symptoms than was the normal BMI group (odds ratio (OR) 1.81; 95% CI 1.10-2.96). Compared to the normal BMI group, generic physical health status was worse in the overweight (mean score decrement -2.42 points; 95% CI -4.39 to -0.45) and the obese groups (-6.31 points; 95% CI -8.14 to -4.49). Asthma-specific quality of life was worse in the underweight (mean score increment 8.66 points; 95% CI 2.53-14.8) and obese groups (4.51 points; 95% CI 2.21-6.81), compared to those with normal BMI. Obese persons also had a higher number of restricted activity days that past month (5.05 days; 95% CI 2.90-7.19 days).

DISCUSSION

It appears that obesity has a substantive negative effect on health status among adults with asthma. Further work is needed to clarify the precise mechanisms. Clinicians should counsel dietary modification and weight loss for their overweight and obese patients with asthma.

Authors+Show Affiliations

Division of Occupational and Environmental Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, California, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18223627

Citation

Vortmann, Michael, and Mark D. Eisner. "BMI and Health Status Among Adults With Asthma." Obesity (Silver Spring, Md.), vol. 16, no. 1, 2008, pp. 146-52.
Vortmann M, Eisner MD. BMI and health status among adults with asthma. Obesity (Silver Spring). 2008;16(1):146-52.
Vortmann, M., & Eisner, M. D. (2008). BMI and health status among adults with asthma. Obesity (Silver Spring, Md.), 16(1), pp. 146-52. doi:10.1038/oby.2007.7.
Vortmann M, Eisner MD. BMI and Health Status Among Adults With Asthma. Obesity (Silver Spring). 2008;16(1):146-52. PubMed PMID: 18223627.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BMI and health status among adults with asthma. AU - Vortmann,Michael, AU - Eisner,Mark D, PY - 2008/1/29/pubmed PY - 2008/4/9/medline PY - 2008/1/29/entrez SP - 146 EP - 52 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 16 IS - 1 N2 - BACKGROUND: A convincing body of literature links obesity with a higher risk for developing adult-onset asthma. The impact of obesity on asthma severity among adults with pre-existing asthma, however, is less clear. METHODS AND PROCEDURES: In a prospective cohort study of 843 adults with severe asthma, we studied the impact of BMI on asthma health status. RESULTS: The prevalence of obesity and overweight were 44% (95% confidence interval (CI) 41-47%) and 28% (95% CI 25-32%). The obese BMI group was associated with a higher risk for daily or near daily asthma symptoms than was the normal BMI group (odds ratio (OR) 1.81; 95% CI 1.10-2.96). Compared to the normal BMI group, generic physical health status was worse in the overweight (mean score decrement -2.42 points; 95% CI -4.39 to -0.45) and the obese groups (-6.31 points; 95% CI -8.14 to -4.49). Asthma-specific quality of life was worse in the underweight (mean score increment 8.66 points; 95% CI 2.53-14.8) and obese groups (4.51 points; 95% CI 2.21-6.81), compared to those with normal BMI. Obese persons also had a higher number of restricted activity days that past month (5.05 days; 95% CI 2.90-7.19 days). DISCUSSION: It appears that obesity has a substantive negative effect on health status among adults with asthma. Further work is needed to clarify the precise mechanisms. Clinicians should counsel dietary modification and weight loss for their overweight and obese patients with asthma. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/18223627/BMI_and_health_status_among_adults_with_asthma_ L2 - https://doi.org/10.1038/oby.2007.7 DB - PRIME DP - Unbound Medicine ER -