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Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Inflamm Res. 2007 Nov; 56(11):459-67.IR

Abstract

OBJECTIVE

The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined.

MATERIALS AND METHODS

PMA dissolved in acetone and acetone were applied to the ears of TRPV1 receptor knockout and wild-type mice. Different groups of animals received ibuprofen, anti-interleukin-1 beta (IL-1beta) antibody, resiniferatoxin (RTX) or capsaicin pretreatment. Ear thickness, myeloperoxidase activity and IL-1beta content of the ears were determined. Histological evaluation was performed.

RESULTS

PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment. Neither the lack of TRPV1 receptors nor anti-IL-1beta antibody prevented sensitizing effect.

CONCLUSIONS

The TRPV1 receptor-independent potentiating action of PMA on contralateral acetone-induced ear oedema is mediated via capsaicin-sensitive afferents and prostanoids are involved. IL-1beta is not essential in this process.

Authors+Show Affiliations

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Pécs, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18224287

Citation

Pozsgai, G, et al. "Topical Acetone Treatment Induces Neurogenic Oedema On the Sensitized Mouse Ear: an in Vivo Study Using Transient Receptor Potential Vanilloid 1 (TRPV1) Receptor Knockout Mice." Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], vol. 56, no. 11, 2007, pp. 459-67.
Pozsgai G, Sándor K, Perkecz A, et al. Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. Inflamm Res. 2007;56(11):459-67.
Pozsgai, G., Sándor, K., Perkecz, A., Szolcsányi, J., Helyes, Z., Brain, S. D., & Pintér, E. (2007). Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.], 56(11), 459-67. https://doi.org/10.1007/s00011-007-7065-7
Pozsgai G, et al. Topical Acetone Treatment Induces Neurogenic Oedema On the Sensitized Mouse Ear: an in Vivo Study Using Transient Receptor Potential Vanilloid 1 (TRPV1) Receptor Knockout Mice. Inflamm Res. 2007;56(11):459-67. PubMed PMID: 18224287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. AU - Pozsgai,G, AU - Sándor,K, AU - Perkecz,A, AU - Szolcsányi,J, AU - Helyes,Z, AU - Brain,S D, AU - Pintér,E, PY - 2008/1/29/pubmed PY - 2008/7/11/medline PY - 2008/1/29/entrez SP - 459 EP - 67 JF - Inflammation research : official journal of the European Histamine Research Society ... [et al.] JO - Inflamm Res VL - 56 IS - 11 N2 - OBJECTIVE: The participation of sensory neurons and transient receptor potential vanilloid 1 (TRPV1) receptors in phorbol 12-myristate 13-acetate (PMA)-induced nerve-sensitizing effect was examined. MATERIALS AND METHODS: PMA dissolved in acetone and acetone were applied to the ears of TRPV1 receptor knockout and wild-type mice. Different groups of animals received ibuprofen, anti-interleukin-1 beta (IL-1beta) antibody, resiniferatoxin (RTX) or capsaicin pretreatment. Ear thickness, myeloperoxidase activity and IL-1beta content of the ears were determined. Histological evaluation was performed. RESULTS: PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment. Neither the lack of TRPV1 receptors nor anti-IL-1beta antibody prevented sensitizing effect. CONCLUSIONS: The TRPV1 receptor-independent potentiating action of PMA on contralateral acetone-induced ear oedema is mediated via capsaicin-sensitive afferents and prostanoids are involved. IL-1beta is not essential in this process. SN - 1023-3830 UR - https://www.unboundmedicine.com/medline/citation/18224287/Topical_acetone_treatment_induces_neurogenic_oedema_on_the_sensitized_mouse_ear:_an_in_vivo_study_using_transient_receptor_potential_vanilloid_1__TRPV1__receptor_knockout_mice_ L2 - https://dx.doi.org/10.1007/s00011-007-7065-7 DB - PRIME DP - Unbound Medicine ER -