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Macronutrients, fatty acids, cholesterol and renal cell cancer risk.
Int J Cancer 2008; 122(11):2586-9IJ

Abstract

The role of selected macronutrients, fatty acids and cholesterol in the etiology of renal cell carcinoma (RCC) was analyzed using data from a case-control study conducted in 4 Italian areas between 1992 and 2004. Cases were 767 patients with incident, histologically confirmed RCC, admitted to major teaching and general hospitals of the study areas. Controls were 1,534 subjects admitted for acute, nonneoplastic conditions to the same hospitals. Information on dietary habits and nutrient intake was elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (CI) for increasing levels of nutrient intake were estimated after allowance for total energy intake and other potential confounding factors. A direct association with RCC was found for starch intake (OR = 1.9 for highest versus lowest quintile of intake; 95% CI: 1.4-2.6, p-value for trend = 0.001), while an inverse association was found for fats from vegetable sources (OR = 0.6; 95% CI: 0.5-0.8; p-value for trend = 0.002), unsaturated fatty acids (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.0002), and polyunsaturated fatty acids (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.001). Among polyunsaturated fatty acids, linoleic acid (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.0001) and linolenic acid (OR = 0.7; 95% CI: 0.5-1.0; p-value for trend = 0.01) were inversely related to RCC. When 6 major macronutrients were included in the same model, the adverse effect of high intake of starch remained statistically significant, together with the protective effect of polyunsaturated fatty acids. Results were consistent in strata of age, body mass index, treated hypertension, energy intake, stage and family history of RCC.

Authors+Show Affiliations

Unità di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy. epidemiology@cro.it

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18224688

Citation

Bidoli, Ettore, et al. "Macronutrients, Fatty Acids, Cholesterol and Renal Cell Cancer Risk." International Journal of Cancer, vol. 122, no. 11, 2008, pp. 2586-9.
Bidoli E, Talamini R, Zucchetto A, et al. Macronutrients, fatty acids, cholesterol and renal cell cancer risk. Int J Cancer. 2008;122(11):2586-9.
Bidoli, E., Talamini, R., Zucchetto, A., Polesel, J., Bosetti, C., Negri, E., ... La Vecchia, C. (2008). Macronutrients, fatty acids, cholesterol and renal cell cancer risk. International Journal of Cancer, 122(11), pp. 2586-9. doi:10.1002/ijc.23386.
Bidoli E, et al. Macronutrients, Fatty Acids, Cholesterol and Renal Cell Cancer Risk. Int J Cancer. 2008 Jun 1;122(11):2586-9. PubMed PMID: 18224688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macronutrients, fatty acids, cholesterol and renal cell cancer risk. AU - Bidoli,Ettore, AU - Talamini,Renato, AU - Zucchetto,Antonella, AU - Polesel,Jerry, AU - Bosetti,Cristina, AU - Negri,Eva, AU - Maruzzi,Daniele, AU - Montella,Maurizio, AU - Franceschi,Silvia, AU - La Vecchia,Carlo, PY - 2008/1/29/pubmed PY - 2008/5/9/medline PY - 2008/1/29/entrez SP - 2586 EP - 9 JF - International journal of cancer JO - Int. J. Cancer VL - 122 IS - 11 N2 - The role of selected macronutrients, fatty acids and cholesterol in the etiology of renal cell carcinoma (RCC) was analyzed using data from a case-control study conducted in 4 Italian areas between 1992 and 2004. Cases were 767 patients with incident, histologically confirmed RCC, admitted to major teaching and general hospitals of the study areas. Controls were 1,534 subjects admitted for acute, nonneoplastic conditions to the same hospitals. Information on dietary habits and nutrient intake was elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (CI) for increasing levels of nutrient intake were estimated after allowance for total energy intake and other potential confounding factors. A direct association with RCC was found for starch intake (OR = 1.9 for highest versus lowest quintile of intake; 95% CI: 1.4-2.6, p-value for trend = 0.001), while an inverse association was found for fats from vegetable sources (OR = 0.6; 95% CI: 0.5-0.8; p-value for trend = 0.002), unsaturated fatty acids (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.0002), and polyunsaturated fatty acids (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.001). Among polyunsaturated fatty acids, linoleic acid (OR = 0.5; 95% CI: 0.4-0.7; p-value for trend = 0.0001) and linolenic acid (OR = 0.7; 95% CI: 0.5-1.0; p-value for trend = 0.01) were inversely related to RCC. When 6 major macronutrients were included in the same model, the adverse effect of high intake of starch remained statistically significant, together with the protective effect of polyunsaturated fatty acids. Results were consistent in strata of age, body mass index, treated hypertension, energy intake, stage and family history of RCC. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/18224688/Macronutrients_fatty_acids_cholesterol_and_renal_cell_cancer_risk_ L2 - https://doi.org/10.1002/ijc.23386 DB - PRIME DP - Unbound Medicine ER -