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Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression.
J Psychiatr Res. 2008 Oct; 42(12):991-9.JP

Abstract

Acute administration of cortisol increases non-rapid-eye movement (non-REM) sleep, suppresses rapid-eye movement (REM) sleep and stimulates growth hormone (GH) release in healthy subjects. This study investigates whether cortisol has similar endocrine and electrophysiological effects in patients with depression who typically show a pathological overactivity of the hypothalamus-pituitary-adrenal (HPA) system. Fifteen depressed inpatients underwent the combined dexamethasone/corticotropin-releasing hormone test followed by three consecutive sleep EEG recordings in which the patients received placebo (saline) and hourly injections of cortisol (1mg/KG BW). Cortisol increased duration and intensity of non-REM sleep in particular in male patients and stimulated GH release. The activity of the HPA axis appeared to influence the cortisol-induced effects on non-REM sleep and GH levels. Stimulation of delta sleep was less pronounced in patients with dexamethasone nonsuppression. In contrast, REM sleep parameters were not affected by the treatment. These data demonstrate that the non-REM sleep-promoting effects of acute cortisol injections observed in healthy controls could be replicated in patients with depression. Our results suggest that non-REM and REM sleep abnormalities during the acute state of the disease are differentially linked to the activity of the HPA axis.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, 80804 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18226817

Citation

Schmid, Dagmar A., et al. "Acute Cortisol Administration Increases Sleep Depth and Growth Hormone Release in Patients With Major Depression." Journal of Psychiatric Research, vol. 42, no. 12, 2008, pp. 991-9.
Schmid DA, Brunner H, Lauer CJ, et al. Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. J Psychiatr Res. 2008;42(12):991-9.
Schmid, D. A., Brunner, H., Lauer, C. J., Uhr, M., Yassouridis, A., Holsboer, F., & Friess, E. (2008). Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. Journal of Psychiatric Research, 42(12), 991-9. https://doi.org/10.1016/j.jpsychires.2007.12.003
Schmid DA, et al. Acute Cortisol Administration Increases Sleep Depth and Growth Hormone Release in Patients With Major Depression. J Psychiatr Res. 2008;42(12):991-9. PubMed PMID: 18226817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. AU - Schmid,Dagmar A, AU - Brunner,Hans, AU - Lauer,Christoph J, AU - Uhr,Manfred, AU - Yassouridis,Alexander, AU - Holsboer,Florian, AU - Friess,Elisabeth, Y1 - 2008/01/28/ PY - 2007/07/30/received PY - 2007/10/29/revised PY - 2007/12/06/accepted PY - 2008/1/30/pubmed PY - 2008/10/31/medline PY - 2008/1/30/entrez SP - 991 EP - 9 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 42 IS - 12 N2 - Acute administration of cortisol increases non-rapid-eye movement (non-REM) sleep, suppresses rapid-eye movement (REM) sleep and stimulates growth hormone (GH) release in healthy subjects. This study investigates whether cortisol has similar endocrine and electrophysiological effects in patients with depression who typically show a pathological overactivity of the hypothalamus-pituitary-adrenal (HPA) system. Fifteen depressed inpatients underwent the combined dexamethasone/corticotropin-releasing hormone test followed by three consecutive sleep EEG recordings in which the patients received placebo (saline) and hourly injections of cortisol (1mg/KG BW). Cortisol increased duration and intensity of non-REM sleep in particular in male patients and stimulated GH release. The activity of the HPA axis appeared to influence the cortisol-induced effects on non-REM sleep and GH levels. Stimulation of delta sleep was less pronounced in patients with dexamethasone nonsuppression. In contrast, REM sleep parameters were not affected by the treatment. These data demonstrate that the non-REM sleep-promoting effects of acute cortisol injections observed in healthy controls could be replicated in patients with depression. Our results suggest that non-REM and REM sleep abnormalities during the acute state of the disease are differentially linked to the activity of the HPA axis. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/18226817/Acute_cortisol_administration_increases_sleep_depth_and_growth_hormone_release_in_patients_with_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(07)00210-5 DB - PRIME DP - Unbound Medicine ER -