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High level ciprofloxacin resistance in Salmonella enterica isolated from blood.
Indian J Med Microbiol. 2008 Jan-Mar; 26(1):50-3.IJ

Abstract

PURPOSE

Over the last few years, resistance to ciprofloxacin in Salmonella enterica has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital.

METHODS

Blood cultures were done using BacT/ALERT 3D system. The antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method using CLSI breakpoints. Minimum inhibitory concentration was determined for ciprofloxacin-resistant strains using E-test and Vitek-1 automated system.

RESULTS

A total of 25,953 samples of blood culture yielded 431 Salmonella enterica serotype Typhi and 198 serotype Paratyphi A isolates. Twenty-two isolates of serotype Typhi were resistant to ciprofloxacin, while two isolates of Typhi and two Paratyphi A were intermediately susceptible to ciprofloxacin. Ciprofloxacin resistance is 5.6% (24 isolates) among Salmonella enterica serotype Typhi. Ampicillin, chloramphenicol and co-trimoxazole resistance in Salmonella enterica serotype Typhi appears to have decreased to 14.9% (64/431) in comparison to the 27% (55/205) during 2003. All isolates were sensitive to ceftriaxone.

CONCLUSIONS

Ciprofloxacin can no longer be considered as the drug of choice in treating Salmonella infections. While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella infections.

Authors+Show Affiliations

Department of Clinical Microbiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi - 110 060, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18227598

Citation

Raveendran, R, et al. "High Level Ciprofloxacin Resistance in Salmonella Enterica Isolated From Blood." Indian Journal of Medical Microbiology, vol. 26, no. 1, 2008, pp. 50-3.
Raveendran R, Wattal C, Sharma A, et al. High level ciprofloxacin resistance in Salmonella enterica isolated from blood. Indian J Med Microbiol. 2008;26(1):50-3.
Raveendran, R., Wattal, C., Sharma, A., Oberoi, J. K., Prasad, K. J., & Datta, S. (2008). High level ciprofloxacin resistance in Salmonella enterica isolated from blood. Indian Journal of Medical Microbiology, 26(1), 50-3.
Raveendran R, et al. High Level Ciprofloxacin Resistance in Salmonella Enterica Isolated From Blood. Indian J Med Microbiol. 2008 Jan-Mar;26(1):50-3. PubMed PMID: 18227598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High level ciprofloxacin resistance in Salmonella enterica isolated from blood. AU - Raveendran,R, AU - Wattal,C, AU - Sharma,A, AU - Oberoi,J K, AU - Prasad,K J, AU - Datta,S, PY - 2008/1/30/pubmed PY - 2008/5/22/medline PY - 2008/1/30/entrez SP - 50 EP - 3 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 26 IS - 1 N2 - PURPOSE: Over the last few years, resistance to ciprofloxacin in Salmonella enterica has become a global concern. The present study was undertaken to find out the susceptibility pattern of Salmonella enterica isolates in our hospital. METHODS: Blood cultures were done using BacT/ALERT 3D system. The antimicrobial susceptibility testing was carried out by the Kirby-Bauer disc diffusion method using CLSI breakpoints. Minimum inhibitory concentration was determined for ciprofloxacin-resistant strains using E-test and Vitek-1 automated system. RESULTS: A total of 25,953 samples of blood culture yielded 431 Salmonella enterica serotype Typhi and 198 serotype Paratyphi A isolates. Twenty-two isolates of serotype Typhi were resistant to ciprofloxacin, while two isolates of Typhi and two Paratyphi A were intermediately susceptible to ciprofloxacin. Ciprofloxacin resistance is 5.6% (24 isolates) among Salmonella enterica serotype Typhi. Ampicillin, chloramphenicol and co-trimoxazole resistance in Salmonella enterica serotype Typhi appears to have decreased to 14.9% (64/431) in comparison to the 27% (55/205) during 2003. All isolates were sensitive to ceftriaxone. CONCLUSIONS: Ciprofloxacin can no longer be considered as the drug of choice in treating Salmonella infections. While first-line antimicrobials may still have a role to play in the treatment of enteric fever, ceftriaxone remains the sole defence against ciprofloxacin-resistant Salmonella infections. SN - 0255-0857 UR - https://www.unboundmedicine.com/medline/citation/18227598/High_level_ciprofloxacin_resistance_in_Salmonella_enterica_isolated_from_blood_ L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2008;volume=26;issue=1;spage=50;epage=53;aulast=Raveendran DB - PRIME DP - Unbound Medicine ER -