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Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects.
Int J Obes (Lond). 2008 May; 32(5):788-94.IJ

Abstract

BACKGROUND

Little is known about the altered cardiac autonomic function (CAF) across different levels of body mass index (BMI), including underweight, normal weight, overweight and obesity. This study provides a thorough analysis to clarify the CAF change in subjects with underweight, overweight and obesity.

METHODS

According to the World Health Organization (WHO) Asia-Pacific BMI cutoffs, a total of 1437 participants were classified as underweight (n=74), normal weight (n=588), overweight (n=313), obesity I (n=390) and obesity II (n=72). CAF was determined by standard deviation of normal-to-normal (SDNN) intervals or RR intervals, power spectrum in low (LF) and high frequency (HF) (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz), and LF/HF ratio at supine for 5 min, the ratio between the 30th and the 15th RR interval after standing from the supine position (30/15 ratio) and the average heart-rate change while taking six deep breaths in 1 min (HR(DB)).

RESULTS

There were significant differences in age, gender, socioeconomic status, blood pressure, HOMA insulin resistance index, fasting glucose, cholesterol, triglyceride and high-density lipoprotein (HDL)-C, and the prevalence of hypertension, ischemic/left bundle branch block (LBBB) electrocardiography (EKG) pattern, current smoking and alcohol use among subjects with underweight, normal weight, overweight, obesity I and II. Univariate analysis showed that SDNN, HR(DB), HF power and the square root of the LF/HF ratio differed among these five groups. Multivariate analysis showed that obesity I and II were inverse correlates of HR(DB) and HF power. Overweight, obesity I and II were positively associated with the square root of the LF/HF ratio. No BMI status was related to SDNN, 30/15 ratio or LF power. Underweight was not the independent correlate of any CAF indices.

CONCLUSIONS

The risk for altered CAF is significant in overweight and obese subjects, independent of cardiovascular risk factors. Underweight is not apparently associated with CAF change.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Wu JS
Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Lu FH
No affiliation info available
Yang YC
No affiliation info available
Lin TS
No affiliation info available
Huang YH
No affiliation info available
Wu CH
No affiliation info available
Chen JJ
No affiliation info available
Chang CJ
No affiliation info available

MeSH

AdultAutonomic Nervous SystemCoronary DiseaseFemaleHeart RateHumansMaleObesityOverweightThinness

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18227846

Citation

Wu, J-S, et al. "Epidemiological Evidence of Altered Cardiac Autonomic Function in Overweight but Not Underweight Subjects." International Journal of Obesity (2005), vol. 32, no. 5, 2008, pp. 788-94.
Wu JS, Lu FH, Yang YC, et al. Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects. Int J Obes (Lond). 2008;32(5):788-94.
Wu, J. S., Lu, F. H., Yang, Y. C., Lin, T. S., Huang, Y. H., Wu, C. H., Chen, J. J., & Chang, C. J. (2008). Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects. International Journal of Obesity (2005), 32(5), 788-94. https://doi.org/10.1038/sj.ijo.0803791
Wu JS, et al. Epidemiological Evidence of Altered Cardiac Autonomic Function in Overweight but Not Underweight Subjects. Int J Obes (Lond). 2008;32(5):788-94. PubMed PMID: 18227846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological evidence of altered cardiac autonomic function in overweight but not underweight subjects. AU - Wu,J-S, AU - Lu,F H, AU - Yang,Y-C, AU - Lin,T-S, AU - Huang,Y-H, AU - Wu,C-H, AU - Chen,J-J, AU - Chang,C-J, Y1 - 2008/01/29/ PY - 2008/1/30/pubmed PY - 2008/8/12/medline PY - 2008/1/30/entrez SP - 788 EP - 94 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 32 IS - 5 N2 - BACKGROUND: Little is known about the altered cardiac autonomic function (CAF) across different levels of body mass index (BMI), including underweight, normal weight, overweight and obesity. This study provides a thorough analysis to clarify the CAF change in subjects with underweight, overweight and obesity. METHODS: According to the World Health Organization (WHO) Asia-Pacific BMI cutoffs, a total of 1437 participants were classified as underweight (n=74), normal weight (n=588), overweight (n=313), obesity I (n=390) and obesity II (n=72). CAF was determined by standard deviation of normal-to-normal (SDNN) intervals or RR intervals, power spectrum in low (LF) and high frequency (HF) (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz), and LF/HF ratio at supine for 5 min, the ratio between the 30th and the 15th RR interval after standing from the supine position (30/15 ratio) and the average heart-rate change while taking six deep breaths in 1 min (HR(DB)). RESULTS: There were significant differences in age, gender, socioeconomic status, blood pressure, HOMA insulin resistance index, fasting glucose, cholesterol, triglyceride and high-density lipoprotein (HDL)-C, and the prevalence of hypertension, ischemic/left bundle branch block (LBBB) electrocardiography (EKG) pattern, current smoking and alcohol use among subjects with underweight, normal weight, overweight, obesity I and II. Univariate analysis showed that SDNN, HR(DB), HF power and the square root of the LF/HF ratio differed among these five groups. Multivariate analysis showed that obesity I and II were inverse correlates of HR(DB) and HF power. Overweight, obesity I and II were positively associated with the square root of the LF/HF ratio. No BMI status was related to SDNN, 30/15 ratio or LF power. Underweight was not the independent correlate of any CAF indices. CONCLUSIONS: The risk for altered CAF is significant in overweight and obese subjects, independent of cardiovascular risk factors. Underweight is not apparently associated with CAF change. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/18227846/Epidemiological_evidence_of_altered_cardiac_autonomic_function_in_overweight_but_not_underweight_subjects_ DB - PRIME DP - Unbound Medicine ER -