Tags

Type your tag names separated by a space and hit enter

[Clinical and molecular consequences of microsatellite instability in human cancers].
Bull Cancer. 2008 Jan; 95(1):121-32.BC

Abstract

During each cell division, DNA polymerase makes mistakes while copying DNA. These errors, more frequent at the level of repeated sequences called microsatellites are normally repaired by a system called MMR (mismatch repair). Tumors defective in their MMR system accumulate mutations (deletions and insertions of some nucleotides) at the level of microsatellites and are called MSI (microsatellite instability). Microsatellites are numerous and scattered throughout the genome, in coding and non-coding regions. The instability of non-coding microsatellites is not known to have a major role in the process of cell transformation, but is a good indicator of the MSI status. On the other hand, instability by deletion or insertion in a coding region leads to a frameshift within the gene containing the repeat. The consequence is, the more often, the inactivation of this gene that potentially plays a role in initiation and/or MSI tumor progression. The MSI phenotype was first described in about 15 % of colorectal cancers that maybe of sporadic or hereditary (Lynch syndrome, or HNPCC for hereditary non-polyposis colorectal cancer) origin. It is also associated with about 15 % of gastric and endometrial tumors, and to a lesser extent with other human tumors. Besides a fundamental interest because of its original transformation mechanism, the analysis of MSI tumors is also important for clinical reasons. It was indeed shown that MSI tumors were associated with a better prognosis than non-MSI (also called MSS for microsatellite stable) tumors, and responded differently to conventional chemotherapeutic drugs used for the management of colorectal cancers. All these points will be discussed in details in the present review.

Authors+Show Affiliations

Inserm, UMRS 762, 27 rue Juliette Dodu, 75010 Paris, France. richard.hamelin@cephb.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

18230578

Citation

Hamelin, Richard, et al. "[Clinical and Molecular Consequences of Microsatellite Instability in Human Cancers]." Bulletin Du Cancer, vol. 95, no. 1, 2008, pp. 121-32.
Hamelin R, Chalastanis A, Colas C, et al. [Clinical and molecular consequences of microsatellite instability in human cancers]. Bull Cancer. 2008;95(1):121-32.
Hamelin, R., Chalastanis, A., Colas, C., El Bchiri, J., Mercier, D., Schreurs, A. S., Simon, V., Svrcek, M., Zaanan, A., Borie, C., Buhard, O., Capel, E., Zouali, H., Praz, F., Muleris, M., Fléjou, J. F., & Duval, A. (2008). [Clinical and molecular consequences of microsatellite instability in human cancers]. Bulletin Du Cancer, 95(1), 121-32. https://doi.org/10.1684/bdc.2008.0571
Hamelin R, et al. [Clinical and Molecular Consequences of Microsatellite Instability in Human Cancers]. Bull Cancer. 2008;95(1):121-32. PubMed PMID: 18230578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical and molecular consequences of microsatellite instability in human cancers]. AU - Hamelin,Richard, AU - Chalastanis,Alexandra, AU - Colas,Chrystelle, AU - El Bchiri,Jamila, AU - Mercier,Dominique, AU - Schreurs,Ann-Sofie, AU - Simon,Virginie, AU - Svrcek,Magali, AU - Zaanan,Aziz, AU - Borie,Claire, AU - Buhard,Olivier, AU - Capel,Emilie, AU - Zouali,Habib, AU - Praz,Françoise, AU - Muleris,Martine, AU - Fléjou,Jean-François, AU - Duval,Alex, PY - 2008/1/31/pubmed PY - 2008/2/20/medline PY - 2008/1/31/entrez SP - 121 EP - 32 JF - Bulletin du cancer JO - Bull Cancer VL - 95 IS - 1 N2 - During each cell division, DNA polymerase makes mistakes while copying DNA. These errors, more frequent at the level of repeated sequences called microsatellites are normally repaired by a system called MMR (mismatch repair). Tumors defective in their MMR system accumulate mutations (deletions and insertions of some nucleotides) at the level of microsatellites and are called MSI (microsatellite instability). Microsatellites are numerous and scattered throughout the genome, in coding and non-coding regions. The instability of non-coding microsatellites is not known to have a major role in the process of cell transformation, but is a good indicator of the MSI status. On the other hand, instability by deletion or insertion in a coding region leads to a frameshift within the gene containing the repeat. The consequence is, the more often, the inactivation of this gene that potentially plays a role in initiation and/or MSI tumor progression. The MSI phenotype was first described in about 15 % of colorectal cancers that maybe of sporadic or hereditary (Lynch syndrome, or HNPCC for hereditary non-polyposis colorectal cancer) origin. It is also associated with about 15 % of gastric and endometrial tumors, and to a lesser extent with other human tumors. Besides a fundamental interest because of its original transformation mechanism, the analysis of MSI tumors is also important for clinical reasons. It was indeed shown that MSI tumors were associated with a better prognosis than non-MSI (also called MSS for microsatellite stable) tumors, and responded differently to conventional chemotherapeutic drugs used for the management of colorectal cancers. All these points will be discussed in details in the present review. SN - 1769-6917 UR - https://www.unboundmedicine.com/medline/citation/18230578/[Clinical_and_molecular_consequences_of_microsatellite_instability_in_human_cancers]_ L2 - http://www.jle.com/medline.md?issn=0007-4551&vol=95&iss=1&page=121 DB - PRIME DP - Unbound Medicine ER -