Tags

Type your tag names separated by a space and hit enter

Role of the endocannabinoid system in energy balance regulation and obesity.
Front Horm Res. 2008; 36:135-145.FH

Abstract

The endogenous cannabinoid system (ECS) is a neuromodulatory system recently recognized to have a role in the regulation of various aspects of eating behavior and energy balance through central and peripheral mechanisms. In the central nervous system, cannabinoid type 1 receptors and their endogenous ligands, the endocannabinoids, are involved in modulating food intake and motivation to consume palatable food. Moreover, the ECS is present in peripheral organs, such as liver, white adipose tissue, muscle, and pancreas, where it seems to be involved in the regulation of lipid and glucose homeostasis. Dysregulation of the ECS has been associated with the development of obesity and its sequelae, such as dyslipidemia and diabetes. Conversely, recent clinical trials have shown that cannabinoid type 1 receptor blockade may ameliorate these metabolic abnormalities. Although further investigation is needed to better define the actual mechanisms of action, pharmacologic approaches targeting the ECS may provide a novel, effective option for the management of obesity, type 2 diabetes and cardiovascular disease.

Authors+Show Affiliations

Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18230900

Citation

Cota, Daniela. "Role of the Endocannabinoid System in Energy Balance Regulation and Obesity." Frontiers of Hormone Research, vol. 36, 2008, pp. 135-145.
Cota D. Role of the endocannabinoid system in energy balance regulation and obesity. Front Horm Res. 2008;36:135-145.
Cota, D. (2008). Role of the endocannabinoid system in energy balance regulation and obesity. Frontiers of Hormone Research, 36, 135-145. https://doi.org/10.1159/000115362
Cota D. Role of the Endocannabinoid System in Energy Balance Regulation and Obesity. Front Horm Res. 2008;36:135-145. PubMed PMID: 18230900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the endocannabinoid system in energy balance regulation and obesity. A1 - Cota,Daniela, PY - 2008/1/31/pubmed PY - 2008/5/8/medline PY - 2008/1/31/entrez SP - 135 EP - 145 JF - Frontiers of hormone research JO - Front Horm Res VL - 36 N2 - The endogenous cannabinoid system (ECS) is a neuromodulatory system recently recognized to have a role in the regulation of various aspects of eating behavior and energy balance through central and peripheral mechanisms. In the central nervous system, cannabinoid type 1 receptors and their endogenous ligands, the endocannabinoids, are involved in modulating food intake and motivation to consume palatable food. Moreover, the ECS is present in peripheral organs, such as liver, white adipose tissue, muscle, and pancreas, where it seems to be involved in the regulation of lipid and glucose homeostasis. Dysregulation of the ECS has been associated with the development of obesity and its sequelae, such as dyslipidemia and diabetes. Conversely, recent clinical trials have shown that cannabinoid type 1 receptor blockade may ameliorate these metabolic abnormalities. Although further investigation is needed to better define the actual mechanisms of action, pharmacologic approaches targeting the ECS may provide a novel, effective option for the management of obesity, type 2 diabetes and cardiovascular disease. SN - 0301-3073 UR - https://www.unboundmedicine.com/medline/citation/18230900/Role_of_the_endocannabinoid_system_in_energy_balance_regulation_and_obesity_ L2 - https://www.karger.com?DOI=10.1159/000115362 DB - PRIME DP - Unbound Medicine ER -