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Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro.
Platelets. 2008 Feb; 19(1):70-7.P

Abstract

The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and anti-platelet commercial monomeric polyphenol-resveratrol. The effects of extracts on platelet adhesion to collagen, collagen-induced platelet aggregation and on the production of O2-* in resting platelets and platelets stimulated by a strong platelet agonist-thrombin were studied. The in vitro experiments have shown that all three tested extracts (5-50 microg/ml) rich in polyphenols reduce platelet adhesion, aggregation and generation of O2-* in blood platelets. Comparative studies indicate that all three plant extracts were found to be more reactive in reduction of platelet processes than the solution of pure resveratrol. The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved.

Authors+Show Affiliations

Department of General Biochemistry, University of Lodz, 90-237 Lodz, Poland. olasb@biol.uni.lodz.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18231940

Citation

Olas, Beata, et al. "Comparative Anti-platelet and Antioxidant Properties of Polyphenol-rich Extracts From: Berries of Aronia Melanocarpa, Seeds of Grape and Bark of Yucca Schidigera in Vitro." Platelets, vol. 19, no. 1, 2008, pp. 70-7.
Olas B, Wachowicz B, Tomczak A, et al. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets. 2008;19(1):70-7.
Olas, B., Wachowicz, B., Tomczak, A., Erler, J., Stochmal, A., & Oleszek, W. (2008). Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets, 19(1), 70-7. https://doi.org/10.1080/09537100701708506
Olas B, et al. Comparative Anti-platelet and Antioxidant Properties of Polyphenol-rich Extracts From: Berries of Aronia Melanocarpa, Seeds of Grape and Bark of Yucca Schidigera in Vitro. Platelets. 2008;19(1):70-7. PubMed PMID: 18231940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. AU - Olas,Beata, AU - Wachowicz,Barbara, AU - Tomczak,Anna, AU - Erler,Joachim, AU - Stochmal,Anna, AU - Oleszek,Wieslaw, PY - 2008/1/31/pubmed PY - 2008/6/18/medline PY - 2008/1/31/entrez SP - 70 EP - 7 JF - Platelets JO - Platelets VL - 19 IS - 1 N2 - The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and anti-platelet commercial monomeric polyphenol-resveratrol. The effects of extracts on platelet adhesion to collagen, collagen-induced platelet aggregation and on the production of O2-* in resting platelets and platelets stimulated by a strong platelet agonist-thrombin were studied. The in vitro experiments have shown that all three tested extracts (5-50 microg/ml) rich in polyphenols reduce platelet adhesion, aggregation and generation of O2-* in blood platelets. Comparative studies indicate that all three plant extracts were found to be more reactive in reduction of platelet processes than the solution of pure resveratrol. The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved. SN - 1369-1635 UR - https://www.unboundmedicine.com/medline/citation/18231940/Comparative_anti_platelet_and_antioxidant_properties_of_polyphenol_rich_extracts_from:_berries_of_Aronia_melanocarpa_seeds_of_grape_and_bark_of_Yucca_schidigera_in_vitro_ L2 - http://www.tandfonline.com/doi/full/10.1080/09537100701708506 DB - PRIME DP - Unbound Medicine ER -