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Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract.
J Agric Food Chem. 2008 Feb 27; 56(4):1423-7.JA

Abstract

Green tea extract is well-known to reduce the risk of a variety of diseases. Here, we investigated the immunostimulating activity of tea polysaccharide (TPS), one of the main components in green tea extract. The water extracts from mature or immature tea leaves were precipitated by using ethanol at room temperature. The sediment was washed with ethanol and acetone alternately and then dried. We used the phagocytic activity of macrophage-like cells as an indicator of immune function activation. Chemical components were analyzed by HPLC. The immunostimulating activity of TPS from immature leaves extract was higher than that of TPS from mature leaves, and its activities were dependent on the content of strictinin in the leaf extract. Futhermore, a mixture of catechin and TPS that removed polyphenols did not increase the immunostimulating activity. These results suggest that the catechin-polysaccharide complex is a very important molecule in the immunomodulating activity of tea extracts.

Authors+Show Affiliations

National Institute of Vegetable and Tea Science, NARO, Shizuoka, Japan. monobe@affrc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18232634

Citation

Monobe, Manami, et al. "Immunostimulating Activity of a Crude Polysaccharide Derived From Green Tea (Camellia Sinensis) Extract." Journal of Agricultural and Food Chemistry, vol. 56, no. 4, 2008, pp. 1423-7.
Monobe M, Ema K, Kato F, et al. Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract. J Agric Food Chem. 2008;56(4):1423-7.
Monobe, M., Ema, K., Kato, F., & Maeda-Yamamoto, M. (2008). Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract. Journal of Agricultural and Food Chemistry, 56(4), 1423-7. https://doi.org/10.1021/jf073127h
Monobe M, et al. Immunostimulating Activity of a Crude Polysaccharide Derived From Green Tea (Camellia Sinensis) Extract. J Agric Food Chem. 2008 Feb 27;56(4):1423-7. PubMed PMID: 18232634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunostimulating activity of a crude polysaccharide derived from green tea (Camellia sinensis) extract. AU - Monobe,Manami, AU - Ema,Kaori, AU - Kato,Fumiko, AU - Maeda-Yamamoto,Mari, Y1 - 2008/01/31/ PY - 2008/2/1/pubmed PY - 2008/4/19/medline PY - 2008/2/1/entrez SP - 1423 EP - 7 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 4 N2 - Green tea extract is well-known to reduce the risk of a variety of diseases. Here, we investigated the immunostimulating activity of tea polysaccharide (TPS), one of the main components in green tea extract. The water extracts from mature or immature tea leaves were precipitated by using ethanol at room temperature. The sediment was washed with ethanol and acetone alternately and then dried. We used the phagocytic activity of macrophage-like cells as an indicator of immune function activation. Chemical components were analyzed by HPLC. The immunostimulating activity of TPS from immature leaves extract was higher than that of TPS from mature leaves, and its activities were dependent on the content of strictinin in the leaf extract. Futhermore, a mixture of catechin and TPS that removed polyphenols did not increase the immunostimulating activity. These results suggest that the catechin-polysaccharide complex is a very important molecule in the immunomodulating activity of tea extracts. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/18232634/Immunostimulating_activity_of_a_crude_polysaccharide_derived_from_green_tea__Camellia_sinensis__extract_ L2 - https://doi.org/10.1021/jf073127h DB - PRIME DP - Unbound Medicine ER -