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HLA antigens and antigliadin antibodies in coeliac disease.
Dis Markers. 1991 Nov-Dec; 9(6):313-7.DM

Abstract

Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or DR7 showed lower AGA levels than those DR3 + and/or DR7 positive. The data suggest that these patients could escape diagnosis if screening for those requiring intestinal biopsy is based only on AGA assay. The observation that coeliac children negative for DR3 and DR7 showed lower AGA levels is consistent with clinical and genetic heterogeneity of coeliac disease.

Authors+Show Affiliations

I Clinica Pediatrica, Università La Sapienza, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1823310

Citation

Bonamico, M, et al. "HLA Antigens and Antigliadin Antibodies in Coeliac Disease." Disease Markers, vol. 9, no. 6, 1991, pp. 313-7.
Bonamico M, Morellini M, Mariani P, et al. HLA antigens and antigliadin antibodies in coeliac disease. Dis Markers. 1991;9(6):313-7.
Bonamico, M., Morellini, M., Mariani, P., Triglione, P., Trabace, S., Lulli, P., Cappellacci, S., & Ballati, G. (1991). HLA antigens and antigliadin antibodies in coeliac disease. Disease Markers, 9(6), 313-7.
Bonamico M, et al. HLA Antigens and Antigliadin Antibodies in Coeliac Disease. Dis Markers. 1991;9(6):313-7. PubMed PMID: 1823310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA antigens and antigliadin antibodies in coeliac disease. AU - Bonamico,M, AU - Morellini,M, AU - Mariani,P, AU - Triglione,P, AU - Trabace,S, AU - Lulli,P, AU - Cappellacci,S, AU - Ballati,G, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 313 EP - 7 JF - Disease markers JO - Dis. Markers VL - 9 IS - 6 N2 - Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or DR7 showed lower AGA levels than those DR3 + and/or DR7 positive. The data suggest that these patients could escape diagnosis if screening for those requiring intestinal biopsy is based only on AGA assay. The observation that coeliac children negative for DR3 and DR7 showed lower AGA levels is consistent with clinical and genetic heterogeneity of coeliac disease. SN - 0278-0240 UR - https://www.unboundmedicine.com/medline/citation/1823310/HLA_antigens_and_antigliadin_antibodies_in_coeliac_disease_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -