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HLA B51 antigen associated with neutrophil hyper-reactivity.
Dis Markers. 1991 Nov-Dec; 9(6):327-31.DM

Abstract

HLA B51 specificity is strongly associated with Behcet's disease (BD) (for references see Baricordi et al., 1986), a multisystem vasculitis of unknown aetiology, for which an immunological pathogenesis has been proposed (O'Duffy et al., 1983; O'Duffy et al., 1990). Neutrophil abnormalities observed in BD patients even during clinical remission suggest prominent involvement of these phagocytic cells in the pathogenesis of the disease (Niwa et al., 1982). In order to clarify how HLA B51 antigen might confer susceptibility to BD, we have investigated neutrophil function in 13 B51-positive and 13 B51-negative healthy subjects. Lymphocyte spontaneous proliferation and circulating immune complexes were also evaluated. Whereas neutrophils from B51-positive subjects showed an increase in the chemotactic response toward casein (P = 0.003) and LPS (P = 0.033) and also in the PMA-induced superoxide production (P = 0.008) no evidence of enhanced lymphocyte activation emerged. These results suggest that the HLA region can exert a regulatory control on PMN functions.

Authors+Show Affiliations

Istituto di Genetica Medica, Università di Ferrara, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1823311

Citation

Sensi, A, et al. "HLA B51 Antigen Associated With Neutrophil Hyper-reactivity." Disease Markers, vol. 9, no. 6, 1991, pp. 327-31.
Sensi A, Gavioli R, Spisani S, et al. HLA B51 antigen associated with neutrophil hyper-reactivity. Dis Markers. 1991;9(6):327-31.
Sensi, A., Gavioli, R., Spisani, S., Balboni, A., Melchiorri, L., Menicucci, A., Palumbo, G., Traniello, S., & Baricordi, O. R. (1991). HLA B51 antigen associated with neutrophil hyper-reactivity. Disease Markers, 9(6), 327-31.
Sensi A, et al. HLA B51 Antigen Associated With Neutrophil Hyper-reactivity. Dis Markers. 1991 Nov-Dec;9(6):327-31. PubMed PMID: 1823311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA B51 antigen associated with neutrophil hyper-reactivity. AU - Sensi,A, AU - Gavioli,R, AU - Spisani,S, AU - Balboni,A, AU - Melchiorri,L, AU - Menicucci,A, AU - Palumbo,G, AU - Traniello,S, AU - Baricordi,O R, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 327 EP - 31 JF - Disease markers JO - Dis. Markers VL - 9 IS - 6 N2 - HLA B51 specificity is strongly associated with Behcet's disease (BD) (for references see Baricordi et al., 1986), a multisystem vasculitis of unknown aetiology, for which an immunological pathogenesis has been proposed (O'Duffy et al., 1983; O'Duffy et al., 1990). Neutrophil abnormalities observed in BD patients even during clinical remission suggest prominent involvement of these phagocytic cells in the pathogenesis of the disease (Niwa et al., 1982). In order to clarify how HLA B51 antigen might confer susceptibility to BD, we have investigated neutrophil function in 13 B51-positive and 13 B51-negative healthy subjects. Lymphocyte spontaneous proliferation and circulating immune complexes were also evaluated. Whereas neutrophils from B51-positive subjects showed an increase in the chemotactic response toward casein (P = 0.003) and LPS (P = 0.033) and also in the PMA-induced superoxide production (P = 0.008) no evidence of enhanced lymphocyte activation emerged. These results suggest that the HLA region can exert a regulatory control on PMN functions. SN - 0278-0240 UR - https://www.unboundmedicine.com/medline/citation/1823311/HLA_B51_antigen_associated_with_neutrophil_hyper_reactivity_ L2 - https://medlineplus.gov/behcetssyndrome.html DB - PRIME DP - Unbound Medicine ER -