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Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model.
Int J Epidemiol. 2008 Apr; 37(2):356-67.IJ

Abstract

BACKGROUND

Although measles incidence has been reduced to low levels in many countries, the potential exists for HIV-1 infection to enhance measles virus (MV) transmission and hinder measles control and elimination efforts.

METHODS

HIV-1 infection was incorporated into an age-structured, deterministic compartmental model of MV transmission. Parameter estimates were obtained from published studies. The model was then adapted to simulate the introduction of antiretroviral therapy (ART).

RESULTS

The model suggests that prior to the introduction of ART, HIV-1 infection has little impact on the transmission dynamics of MV. High mortality rates in HIV-1-infected children without access to ART counteract the higher rates of vaccine failure, shorter duration of maternal antibody protection and longer duration of infectiousness in HIV-1-infected children, as many of these children die before they are able to contribute to MV transmission. The introduction of ART into the model resulted in an increase in measles prevalence.

CONCLUSIONS

High overall mortality among HIV-1-infected children without access to ART limits the impact of the HIV-1 epidemic on MV transmission and may help to explain the initial success of measles control strategies in Africa. The scaling-up of ART should improve children's survival but could lead to an increase in measles prevalence in the absence of sustained measles control efforts. Further study of the duration of immunity in HIV-1-infected children receiving ART and their response to revaccination is needed to determine whether a second dose of measles vaccine will protect these children and further reduce MV transmission.

Authors+Show Affiliations

London School of Hygiene and Tropical Medicine, London, UK. susana.scott@lshtm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18234739

Citation

Scott, Susana, et al. "Predicted Impact of the HIV-1 Epidemic On Measles in Developing Countries: Results From a Dynamic Age-structured Model." International Journal of Epidemiology, vol. 37, no. 2, 2008, pp. 356-67.
Scott S, Mossong J, Moss WJ, et al. Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model. Int J Epidemiol. 2008;37(2):356-67.
Scott, S., Mossong, J., Moss, W. J., Cutts, F. T., & Cousens, S. (2008). Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model. International Journal of Epidemiology, 37(2), 356-67. https://doi.org/10.1093/ije/dyn007
Scott S, et al. Predicted Impact of the HIV-1 Epidemic On Measles in Developing Countries: Results From a Dynamic Age-structured Model. Int J Epidemiol. 2008;37(2):356-67. PubMed PMID: 18234739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model. AU - Scott,Susana, AU - Mossong,Joel, AU - Moss,William J, AU - Cutts,Felicity T, AU - Cousens,Simon, Y1 - 2008/01/30/ PY - 2008/2/1/pubmed PY - 2008/6/17/medline PY - 2008/2/1/entrez SP - 356 EP - 67 JF - International journal of epidemiology JO - Int J Epidemiol VL - 37 IS - 2 N2 - BACKGROUND: Although measles incidence has been reduced to low levels in many countries, the potential exists for HIV-1 infection to enhance measles virus (MV) transmission and hinder measles control and elimination efforts. METHODS: HIV-1 infection was incorporated into an age-structured, deterministic compartmental model of MV transmission. Parameter estimates were obtained from published studies. The model was then adapted to simulate the introduction of antiretroviral therapy (ART). RESULTS: The model suggests that prior to the introduction of ART, HIV-1 infection has little impact on the transmission dynamics of MV. High mortality rates in HIV-1-infected children without access to ART counteract the higher rates of vaccine failure, shorter duration of maternal antibody protection and longer duration of infectiousness in HIV-1-infected children, as many of these children die before they are able to contribute to MV transmission. The introduction of ART into the model resulted in an increase in measles prevalence. CONCLUSIONS: High overall mortality among HIV-1-infected children without access to ART limits the impact of the HIV-1 epidemic on MV transmission and may help to explain the initial success of measles control strategies in Africa. The scaling-up of ART should improve children's survival but could lead to an increase in measles prevalence in the absence of sustained measles control efforts. Further study of the duration of immunity in HIV-1-infected children receiving ART and their response to revaccination is needed to determine whether a second dose of measles vaccine will protect these children and further reduce MV transmission. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/18234739/Predicted_impact_of_the_HIV_1_epidemic_on_measles_in_developing_countries:_results_from_a_dynamic_age_structured_model_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyn007 DB - PRIME DP - Unbound Medicine ER -