[Pharmacokinetics of pueraria for intranasal on spray in rabbits].Zhong Yao Cai. 2007 Sep; 30(9):1102-5.ZY
To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits.
The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters.
The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h.
The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.