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[Pharmacokinetics of pueraria for intranasal on spray in rabbits].
Zhong Yao Cai. 2007 Sep; 30(9):1102-5.ZY

Abstract

OBJECTIVE

To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits.

METHODS

The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters.

RESULTS

The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h.

CONCLUSION

The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal.

Authors+Show Affiliations

Lu Y
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang T
No affiliation info available
Tao JS
No affiliation info available
Xu LY
No affiliation info available

MeSH

AbsorptionAdministration, IntranasalAerosolsAnimalsArea Under CurveBiological AvailabilityChromatography, High Pressure LiquidDrugs, Chinese HerbalIsoflavonesPlants, MedicinalPuerariaRabbitsTime Factors

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18236755

Citation

Lu, Yi, et al. "[Pharmacokinetics of Pueraria for Intranasal On Spray in Rabbits]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 30, no. 9, 2007, pp. 1102-5.
Lu Y, Zhang T, Tao JS, et al. [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. Zhong Yao Cai. 2007;30(9):1102-5.
Lu, Y., Zhang, T., Tao, J. S., & Xu, L. Y. (2007). [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 30(9), 1102-5.
Lu Y, et al. [Pharmacokinetics of Pueraria for Intranasal On Spray in Rabbits]. Zhong Yao Cai. 2007;30(9):1102-5. PubMed PMID: 18236755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. AU - Lu,Yi, AU - Zhang,Tong, AU - Tao,Jian-sheng, AU - Xu,Lian-ying, PY - 2008/2/2/pubmed PY - 2008/7/25/medline PY - 2008/2/2/entrez SP - 1102 EP - 5 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 30 IS - 9 N2 - OBJECTIVE: To explore pharmacokinetic features of puerarin in pueraria spray and calculate pharmacokinetic parameters according to puerarin of drug-time curve in rabbits. METHODS: The concentration of puerarin in plamsa was determined by HPLC. The methanol was used to sediment protine. The 3P87 program was used to calculate the pharmacokinetic parameters. RESULTS: The vivo course of pueraria in spray could be described by the two compartment model. The main pharmacokinetic parameters of Pueraria spray were: t(l/2(beta)) =0.93 h, CL =44.23 mg x L(-1), AUC = 16.28 mg x h x L(-1), Cmax =5.9 mg x L(-1) and tmax = 0.975 h. CONCLUSION: The study will provide some scientific basises for the quality evaluation and pharmaceutics reformation of pueraria for intranasal. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/18236755/[Pharmacokinetics_of_pueraria_for_intranasal_on_spray_in_rabbits]_ DB - PRIME DP - Unbound Medicine ER -