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Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats.
Pharmazie. 2007 Oct; 62(10):790-7.P

Abstract

In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T. chebula extract (25 and 50 mg/kg body weight) restored the levels of reduced glutathione (GSH) and cellular protective enzymes (p < 0.05). Concomitantly, malondialdehyde (MDA) formation and hydrogen peroxide content were also reduced significantly (p < 0.05) at both the doses. The promotion parameters tested (ornithine decarboxylase activity and DNA synthesis) were also significantly suppressed (p < 0.05). T. chebula also inhibited N-diethyl nitrosamine initiated renal carcinogenesis by showing reduction in the number of animals with renal cell tumors and percentage incidence of tumor as compared to the DEN initiated and Fe-NTA promoted rats. The study was further histologically confirmed. These results suggest a potential role of T. chebula in protection from Fe-NTA-induced renal carcinogenesis and oxidative damage.

Authors+Show Affiliations

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18236787

Citation

Prasad, L, et al. "Abrogation of DEN/Fe-NTA Induced Carcinogenic Response, Oxidative Damage and Subsequent Cell Proliferation Response By Terminalia Chebula in Kidney of Wistar Rats." Die Pharmazie, vol. 62, no. 10, 2007, pp. 790-7.
Prasad L, Khan TH, Jahangir T, et al. Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats. Pharmazie. 2007;62(10):790-7.
Prasad, L., Khan, T. H., Jahangir, T., & Sultana, S. (2007). Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats. Die Pharmazie, 62(10), 790-7.
Prasad L, et al. Abrogation of DEN/Fe-NTA Induced Carcinogenic Response, Oxidative Damage and Subsequent Cell Proliferation Response By Terminalia Chebula in Kidney of Wistar Rats. Pharmazie. 2007;62(10):790-7. PubMed PMID: 18236787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abrogation of DEN/Fe-NTA induced carcinogenic response, oxidative damage and subsequent cell proliferation response by Terminalia chebula in kidney of Wistar rats. AU - Prasad,L, AU - Khan,T H, AU - Jahangir,T, AU - Sultana,S, PY - 2008/2/2/pubmed PY - 2008/2/21/medline PY - 2008/2/2/entrez SP - 790 EP - 7 JF - Die Pharmazie JO - Pharmazie VL - 62 IS - 10 N2 - In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T. chebula extract (25 and 50 mg/kg body weight) restored the levels of reduced glutathione (GSH) and cellular protective enzymes (p < 0.05). Concomitantly, malondialdehyde (MDA) formation and hydrogen peroxide content were also reduced significantly (p < 0.05) at both the doses. The promotion parameters tested (ornithine decarboxylase activity and DNA synthesis) were also significantly suppressed (p < 0.05). T. chebula also inhibited N-diethyl nitrosamine initiated renal carcinogenesis by showing reduction in the number of animals with renal cell tumors and percentage incidence of tumor as compared to the DEN initiated and Fe-NTA promoted rats. The study was further histologically confirmed. These results suggest a potential role of T. chebula in protection from Fe-NTA-induced renal carcinogenesis and oxidative damage. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/18236787/Abrogation_of_DEN/Fe_NTA_induced_carcinogenic_response_oxidative_damage_and_subsequent_cell_proliferation_response_by_Terminalia_chebula_in_kidney_of_Wistar_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -