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Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study.
Int J Cardiol 2008; 125(2):232-9IJ

Abstract

BACKGROUND

The role of serum uric acid (SUA) as a risk factor for cardiovascular disease (CVD) remains controversial. Little is known about its predictive value for mortality from congestive heart failure (CHF) and stroke, particularly in elderly, post-menopausal women.

METHODS

The relation of SUA to risk of death from total CVD, CHF, stroke and coronary heart disease (CHD) was examined prospectively in a large cohort of 28613 elderly Austrian women (mean age 62.3 years), followed-up for a median of 15.2 years. Adjusted Cox proportional hazards models were calculated to evaluate SUA as an independent predictor for fatal CVD events.

RESULTS

SUA in the highest quartile (>or=5.41 mg/dL) was significantly associated with mortality from total CVD (p<0.0001), showing a clear dose-response relationship; the adjusted hazard ratio (95%CI) in comparison to the lowest SUA quartile was 1.35 (1.20-1.52). In subgroup analyses SUA was independently predictive for deaths from acute and subacute (p<0.0001) and chronic forms (p=0.035) of CHD, yielding adjusted hazard ratios for the highest versus lowest SUA quartile of 1.58 (1.19-2.10) and 1.25 (1.01-1.56), respectively. SUA was further significantly related to fatal CHF (p<0.0001) and stroke (p=0.018); the adjusted hazard ratios for the highest versus lowest SUA quartile were 1.50 (1.04-2.17) and 1.37 (1.09-1.74), respectively.

CONCLUSIONS

These findings, for the first time, demonstrate that SUA is an independent predictor for all major forms of death from CVD including acute, subacute and chronic forms of CHD, CHF and stroke in elderly, post-menopausal women.

Authors+Show Affiliations

Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Schoepfstrasse 41, A-6020 Innsbruck, Austria. alexander.strasak@i-med.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18237790

Citation

Strasak, Alexander M., et al. "Serum Uric Acid Is an Independent Predictor for All Major Forms of Cardiovascular Death in 28,613 Elderly Women: a Prospective 21-year Follow-up Study." International Journal of Cardiology, vol. 125, no. 2, 2008, pp. 232-9.
Strasak AM, Kelleher CC, Brant LJ, et al. Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study. Int J Cardiol. 2008;125(2):232-9.
Strasak, A. M., Kelleher, C. C., Brant, L. J., Rapp, K., Ruttmann, E., Concin, H., ... Ulmer, H. (2008). Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study. International Journal of Cardiology, 125(2), pp. 232-9. doi:10.1016/j.ijcard.2007.11.094.
Strasak AM, et al. Serum Uric Acid Is an Independent Predictor for All Major Forms of Cardiovascular Death in 28,613 Elderly Women: a Prospective 21-year Follow-up Study. Int J Cardiol. 2008 Apr 10;125(2):232-9. PubMed PMID: 18237790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum uric acid is an independent predictor for all major forms of cardiovascular death in 28,613 elderly women: a prospective 21-year follow-up study. AU - Strasak,Alexander M, AU - Kelleher,Cecily C, AU - Brant,Larry J, AU - Rapp,Kilian, AU - Ruttmann,Elfriede, AU - Concin,Hans, AU - Diem,Günter, AU - Pfeiffer,Karl P, AU - Ulmer,Hanno, AU - ,, Y1 - 2008/01/30/ PY - 2007/08/05/received PY - 2007/10/29/revised PY - 2007/11/25/accepted PY - 2008/2/2/pubmed PY - 2008/6/11/medline PY - 2008/2/2/entrez SP - 232 EP - 9 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 125 IS - 2 N2 - BACKGROUND: The role of serum uric acid (SUA) as a risk factor for cardiovascular disease (CVD) remains controversial. Little is known about its predictive value for mortality from congestive heart failure (CHF) and stroke, particularly in elderly, post-menopausal women. METHODS: The relation of SUA to risk of death from total CVD, CHF, stroke and coronary heart disease (CHD) was examined prospectively in a large cohort of 28613 elderly Austrian women (mean age 62.3 years), followed-up for a median of 15.2 years. Adjusted Cox proportional hazards models were calculated to evaluate SUA as an independent predictor for fatal CVD events. RESULTS: SUA in the highest quartile (>or=5.41 mg/dL) was significantly associated with mortality from total CVD (p<0.0001), showing a clear dose-response relationship; the adjusted hazard ratio (95%CI) in comparison to the lowest SUA quartile was 1.35 (1.20-1.52). In subgroup analyses SUA was independently predictive for deaths from acute and subacute (p<0.0001) and chronic forms (p=0.035) of CHD, yielding adjusted hazard ratios for the highest versus lowest SUA quartile of 1.58 (1.19-2.10) and 1.25 (1.01-1.56), respectively. SUA was further significantly related to fatal CHF (p<0.0001) and stroke (p=0.018); the adjusted hazard ratios for the highest versus lowest SUA quartile were 1.50 (1.04-2.17) and 1.37 (1.09-1.74), respectively. CONCLUSIONS: These findings, for the first time, demonstrate that SUA is an independent predictor for all major forms of death from CVD including acute, subacute and chronic forms of CHD, CHF and stroke in elderly, post-menopausal women. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18237790/Serum_uric_acid_is_an_independent_predictor_for_all_major_forms_of_cardiovascular_death_in_28613_elderly_women:_a_prospective_21_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(07)02133-X DB - PRIME DP - Unbound Medicine ER -