Tags

Type your tag names separated by a space and hit enter

Economic evaluation of folic acid food fortification in The Netherlands.
Eur J Public Health. 2008 Jun; 18(3):270-4.EJ

Abstract

BACKGROUND

Folic acid intake before and during pregnancy reduces neural tube defects (NTD). Therefore, several countries have enriched bulk food with folic acid resulting in a 26-48% decrease in the prevalence of NTDs. In 2000, the Dutch Health Council advised against folic acid enrichment based on literature research; yet formal cost-effectiveness information was absent. We designed our study to estimate cost-effectiveness of folic acid food fortification in the Netherlands.

METHOD

Prevalence of NTD at birth, life-time costs of care, and folic acid fortification costs were estimated using Dutch registrations, Dutch guidelines for costing, (inter)national literature and expert opinions. Both net cost per discounted life year gained and net cost per discounted quality adjusted life year (QALY) gained were estimated for the base case and sensitivity analyses.

RESULTS

In the base case and most sensitivity analyses, folic acid enrichment was estimated to be cost-saving. Bulk food fortification with folic acid remains cost-effective as long as enrichment costs do not exceed euro5.5 million (threshold at euro20 000 per QALY).

CONCLUSION

Our model suggests that folic acid fortification of bulk food to prevent cases of NTD in newborns might be a cost-saving intervention in the Netherlands. Additionally, besides the evidence that folic acid reduces the number of NTDs, there are indications that folic acid is associated with the prevention of other birth defects, cardiovascular diseases and cancer. Our model did not yet include these possibly beneficial effects.

Authors+Show Affiliations

Graduate Schools SHARE & GUIDE, Department of Social Pharmacy & Pharmacoepidemiology, University of Groningen, Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18238826

Citation

Jentink, Janneke, et al. "Economic Evaluation of Folic Acid Food Fortification in the Netherlands." European Journal of Public Health, vol. 18, no. 3, 2008, pp. 270-4.
Jentink J, van de Vrie-Hoekstra NW, de Jong-van den Berg LT, et al. Economic evaluation of folic acid food fortification in The Netherlands. Eur J Public Health. 2008;18(3):270-4.
Jentink, J., van de Vrie-Hoekstra, N. W., de Jong-van den Berg, L. T., & Postma, M. J. (2008). Economic evaluation of folic acid food fortification in The Netherlands. European Journal of Public Health, 18(3), 270-4. https://doi.org/10.1093/eurpub/ckm129
Jentink J, et al. Economic Evaluation of Folic Acid Food Fortification in the Netherlands. Eur J Public Health. 2008;18(3):270-4. PubMed PMID: 18238826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Economic evaluation of folic acid food fortification in The Netherlands. AU - Jentink,Janneke, AU - van de Vrie-Hoekstra,Nienke W, AU - de Jong-van den Berg,Lolkje T W, AU - Postma,Maarten J, Y1 - 2008/01/31/ PY - 2008/2/2/pubmed PY - 2008/9/3/medline PY - 2008/2/2/entrez SP - 270 EP - 4 JF - European journal of public health JO - Eur J Public Health VL - 18 IS - 3 N2 - BACKGROUND: Folic acid intake before and during pregnancy reduces neural tube defects (NTD). Therefore, several countries have enriched bulk food with folic acid resulting in a 26-48% decrease in the prevalence of NTDs. In 2000, the Dutch Health Council advised against folic acid enrichment based on literature research; yet formal cost-effectiveness information was absent. We designed our study to estimate cost-effectiveness of folic acid food fortification in the Netherlands. METHOD: Prevalence of NTD at birth, life-time costs of care, and folic acid fortification costs were estimated using Dutch registrations, Dutch guidelines for costing, (inter)national literature and expert opinions. Both net cost per discounted life year gained and net cost per discounted quality adjusted life year (QALY) gained were estimated for the base case and sensitivity analyses. RESULTS: In the base case and most sensitivity analyses, folic acid enrichment was estimated to be cost-saving. Bulk food fortification with folic acid remains cost-effective as long as enrichment costs do not exceed euro5.5 million (threshold at euro20 000 per QALY). CONCLUSION: Our model suggests that folic acid fortification of bulk food to prevent cases of NTD in newborns might be a cost-saving intervention in the Netherlands. Additionally, besides the evidence that folic acid reduces the number of NTDs, there are indications that folic acid is associated with the prevention of other birth defects, cardiovascular diseases and cancer. Our model did not yet include these possibly beneficial effects. SN - 1464-360X UR - https://www.unboundmedicine.com/medline/citation/18238826/Economic_evaluation_of_folic_acid_food_fortification_in_The_Netherlands_ L2 - https://academic.oup.com/eurpub/article-lookup/doi/10.1093/eurpub/ckm129 DB - PRIME DP - Unbound Medicine ER -