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Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression.
Am J Geriatr Psychiatry. 2008 Feb; 16(2):168-74.AJ

Abstract

OBJECTIVE

Recent evidence suggests that a history of major depression may lead to increases in hippocampal neuropathology in Alzheimer disease (AD). The authors tested the hypothesis that neuritic plaques and neurofibrillary tangles are more pronounced in the brains of patients with AD with comorbid depression as compared with patients with AD without depression.

METHODS

Brain samples from patients were selected from the U.S. National Alzheimer's Coordinating Center database. The primary analysis included 7164 individuals: 6468 had AD as the primary neuropathologic diagnosis and 696 were considered neuropathologically normal. Depression at study inclusion was rated as present or absent in consensus conferences. Neuropathologic ratings from the Consortium to Establish a Registry in Alzheimer's Disease rating of neuritic plaques and Braak staging of neurofibrillary tangles were used for between-group analyses.

RESULTS

Brains of patients with AD with comorbid depression showed higher levels of cortical tangle formation than brains of patients with AD without comorbid depression. Results remained stable when controlling for age, gender, level of education, and cognitive status. Within patients with AD, comorbid depression increased the odds for advanced neuropathologic disease stage (odds ratio: 1.47; 95% confidence interval: 1.03-2.08).

CONCLUSION

In AD, the presence of depression comorbidity corresponds to increases in AD-related neuropathologic changes beyond age, gender, level of education, and cognitive status, suggesting an interaction between depression and the neuropathologic processes in AD.

Authors+Show Affiliations

Department of Psychiatry, Mount Sinai School of Medicine, New York, USA. michael.rapp@charite.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18239198

Citation

Rapp, Michael A., et al. "Increased Neurofibrillary Tangles in Patients With Alzheimer Disease With Comorbid Depression." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 16, no. 2, 2008, pp. 168-74.
Rapp MA, Schnaider-Beeri M, Purohit DP, et al. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry. 2008;16(2):168-74.
Rapp, M. A., Schnaider-Beeri, M., Purohit, D. P., Perl, D. P., Haroutunian, V., & Sano, M. (2008). Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 16(2), 168-74. https://doi.org/10.1097/JGP.0b013e31816029ec
Rapp MA, et al. Increased Neurofibrillary Tangles in Patients With Alzheimer Disease With Comorbid Depression. Am J Geriatr Psychiatry. 2008;16(2):168-74. PubMed PMID: 18239198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. AU - Rapp,Michael A, AU - Schnaider-Beeri,Michal, AU - Purohit,Dushyant P, AU - Perl,Daniel P, AU - Haroutunian,Vahram, AU - Sano,Mary, PY - 2008/2/2/pubmed PY - 2008/5/15/medline PY - 2008/2/2/entrez SP - 168 EP - 74 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 16 IS - 2 N2 - OBJECTIVE: Recent evidence suggests that a history of major depression may lead to increases in hippocampal neuropathology in Alzheimer disease (AD). The authors tested the hypothesis that neuritic plaques and neurofibrillary tangles are more pronounced in the brains of patients with AD with comorbid depression as compared with patients with AD without depression. METHODS: Brain samples from patients were selected from the U.S. National Alzheimer's Coordinating Center database. The primary analysis included 7164 individuals: 6468 had AD as the primary neuropathologic diagnosis and 696 were considered neuropathologically normal. Depression at study inclusion was rated as present or absent in consensus conferences. Neuropathologic ratings from the Consortium to Establish a Registry in Alzheimer's Disease rating of neuritic plaques and Braak staging of neurofibrillary tangles were used for between-group analyses. RESULTS: Brains of patients with AD with comorbid depression showed higher levels of cortical tangle formation than brains of patients with AD without comorbid depression. Results remained stable when controlling for age, gender, level of education, and cognitive status. Within patients with AD, comorbid depression increased the odds for advanced neuropathologic disease stage (odds ratio: 1.47; 95% confidence interval: 1.03-2.08). CONCLUSION: In AD, the presence of depression comorbidity corresponds to increases in AD-related neuropathologic changes beyond age, gender, level of education, and cognitive status, suggesting an interaction between depression and the neuropathologic processes in AD. SN - 1064-7481 UR - https://www.unboundmedicine.com/medline/citation/18239198/Increased_neurofibrillary_tangles_in_patients_with_Alzheimer_disease_with_comorbid_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/16/2/168 DB - PRIME DP - Unbound Medicine ER -