Anthropometric risk factors for colorectal polyps in African-American women.Obesity (Silver Spring). 2008 Apr; 16(4):859-68.O
Colorectal adenomas are thought to be precursor lesions to colorectal cancer, a leading cause of cancer incidence and mortality in African-American women. Studies suggest that obesity is associated with risk of adenomas in white women, but little is known about the relation in African-American women. We prospectively examined the association between selected anthropometric factors and colorectal polyps in African-American women.
METHODS AND PROCEDURES
Data were obtained from the Black Women's Health Study (BWHS), a prospective cohort study of African-American women. From 1997 to 2003, we followed 33,403 women aged > or =30 years with no prior diagnosis of cancer or polyps. Cox regression was used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs) for risk of polyps, with adjustment for potential confounders.
After 211,797 person-years of follow-up, 1,189 cases of colorectal polyps were reported. The IRR comparing women with a current BMI > or =35 to <25 kg/m(2) was 1.35 (95% CI = 1.12-1.62), after adjustment for covariates including waist-to-hip ratio (WHR). Women who gained > or =30 kg since age 18 were 1.76 times as likely as those who gained <5 kg to report polyps (95% CI = 1.33-2.33). The IRR comparing the highest (>or =0.87) to lowest (<0.71) quintiles of WHR was 1.26 (95% CI = 1.04-1.54), after adjustment for covariates including BMI. BMI at age 18, adult height, and waist circumference (BMI-adjusted) were not materially associated with risk. Results were similar among women with a recent endoscopy.
Weight gain and obesity in adulthood may increase the risk of colorectal polyps in African-American women.