Tags

Type your tag names separated by a space and hit enter

All-cause and cardiovascular disease mortality increased with metabolic syndrome in Taiwanese.
Obesity (Silver Spring) 2008; 16(3):684-9O

Abstract

OBJECTIVE

This study aimed to investigate the relationship between mortality and metabolic syndrome using the America Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) and International Diabetes Federation (IDF) definitions in a Taiwanese cohort.

METHODS AND PROCEDURES

A total of 124,513 participants, aged 20-94 years, from four nationwide health centers in Taiwan were recruited from 1998 to 1999. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) for all-cause and cardiovascular disease (CVD) mortality for those with metabolic syndrome compared to those without metabolic syndrome over 8 years of follow-up.

RESULTS

The baseline prevalence of metabolic syndrome was 22.4% by the AHA/NHLBI and 13.9% by the IDF definition. A total of 2,762 deaths (527 CVD) occurred. Using the AHA/NHLBI definition, the RRs (95% confidence intervals) of all-cause and CVD mortality were 1.21 (1.09-1.34) and 1.77 (1.40-2.24), respectively, in men and 1.30 (1.12-1.49) and 1.69 (1.19-2.42), respectively, in women. The association between metabolic syndrome and mortality was attenuated when using the IDF definition. Excluding subjects with diabetes or CVD at baseline, the RRs for CVD mortality still remained significant using the two definitions.

DISCUSSION

Metabolic syndrome, using either the AHA/NHLBI or IDF definitions, is a common disorder in Taiwanese adults and is similarly associated with an increase in all-cause and CVD mortality as found in Western populations. Our study suggests that Asians with metabolic syndrome are also at higher risk for death.

Authors+Show Affiliations

Department of Family Medicine, National Taiwan University Hospital, Taipei, Taiwan. chin3@ha.mc.ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18239592

Citation

Huang, Kuo-Chin, et al. "All-cause and Cardiovascular Disease Mortality Increased With Metabolic Syndrome in Taiwanese." Obesity (Silver Spring, Md.), vol. 16, no. 3, 2008, pp. 684-9.
Huang KC, Lee LT, Chen CY, et al. All-cause and cardiovascular disease mortality increased with metabolic syndrome in Taiwanese. Obesity (Silver Spring). 2008;16(3):684-9.
Huang, K. C., Lee, L. T., Chen, C. Y., & Sung, P. K. (2008). All-cause and cardiovascular disease mortality increased with metabolic syndrome in Taiwanese. Obesity (Silver Spring, Md.), 16(3), pp. 684-9. doi:10.1038/oby.2007.112.
Huang KC, et al. All-cause and Cardiovascular Disease Mortality Increased With Metabolic Syndrome in Taiwanese. Obesity (Silver Spring). 2008;16(3):684-9. PubMed PMID: 18239592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - All-cause and cardiovascular disease mortality increased with metabolic syndrome in Taiwanese. AU - Huang,Kuo-Chin, AU - Lee,Long-Teng, AU - Chen,Ching-Yu, AU - Sung,Pei-Kun, Y1 - 2008/01/17/ PY - 2008/2/2/pubmed PY - 2008/5/23/medline PY - 2008/2/2/entrez SP - 684 EP - 9 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 16 IS - 3 N2 - OBJECTIVE: This study aimed to investigate the relationship between mortality and metabolic syndrome using the America Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) and International Diabetes Federation (IDF) definitions in a Taiwanese cohort. METHODS AND PROCEDURES: A total of 124,513 participants, aged 20-94 years, from four nationwide health centers in Taiwan were recruited from 1998 to 1999. Cox proportional hazard regression analyses were used to estimate the relative risks (RRs) for all-cause and cardiovascular disease (CVD) mortality for those with metabolic syndrome compared to those without metabolic syndrome over 8 years of follow-up. RESULTS: The baseline prevalence of metabolic syndrome was 22.4% by the AHA/NHLBI and 13.9% by the IDF definition. A total of 2,762 deaths (527 CVD) occurred. Using the AHA/NHLBI definition, the RRs (95% confidence intervals) of all-cause and CVD mortality were 1.21 (1.09-1.34) and 1.77 (1.40-2.24), respectively, in men and 1.30 (1.12-1.49) and 1.69 (1.19-2.42), respectively, in women. The association between metabolic syndrome and mortality was attenuated when using the IDF definition. Excluding subjects with diabetes or CVD at baseline, the RRs for CVD mortality still remained significant using the two definitions. DISCUSSION: Metabolic syndrome, using either the AHA/NHLBI or IDF definitions, is a common disorder in Taiwanese adults and is similarly associated with an increase in all-cause and CVD mortality as found in Western populations. Our study suggests that Asians with metabolic syndrome are also at higher risk for death. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/18239592/All_cause_and_cardiovascular_disease_mortality_increased_with_metabolic_syndrome_in_Taiwanese_ L2 - https://doi.org/10.1038/oby.2007.112 DB - PRIME DP - Unbound Medicine ER -