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Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.
Bull Exp Biol Med. 2007 May; 143(5):601-4.BE

Abstract

Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to "calcium" stress.

Authors+Show Affiliations

Storozhevykh TP
Laboratory of Membranology, Center of Children's Health, Russian Academy of Medical Sciences, Moscow, Russia. tstor@mail.ru
Tukhbatova GR
No affiliation info available
Senilova YE
No affiliation info available
Pinelis VG
No affiliation info available
Andreeva LA
No affiliation info available
Myasoyedov NF
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsCalciumCell SurvivalGlutamic AcidHomeostasisNeuronsOligopeptidesPeptide FragmentsProlineRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18239779

Citation

Storozhevykh, T P., et al. "Effects of Semax and Its Pro-Gly-Pro Fragment On Calcium Homeostasis of Neurons and Their Survival Under Conditions of Glutamate Toxicity." Bulletin of Experimental Biology and Medicine, vol. 143, no. 5, 2007, pp. 601-4.
Storozhevykh TP, Tukhbatova GR, Senilova YE, et al. Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity. Bull Exp Biol Med. 2007;143(5):601-4.
Storozhevykh, T. P., Tukhbatova, G. R., Senilova, Y. E., Pinelis, V. G., Andreeva, L. A., & Myasoyedov, N. F. (2007). Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity. Bulletin of Experimental Biology and Medicine, 143(5), 601-4.
Storozhevykh TP, et al. Effects of Semax and Its Pro-Gly-Pro Fragment On Calcium Homeostasis of Neurons and Their Survival Under Conditions of Glutamate Toxicity. Bull Exp Biol Med. 2007;143(5):601-4. PubMed PMID: 18239779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity. AU - Storozhevykh,T P, AU - Tukhbatova,G R, AU - Senilova,Ya E, AU - Pinelis,V G, AU - Andreeva,L A, AU - Myasoyedov,N F, PY - 2008/2/2/pubmed PY - 2008/3/26/medline PY - 2008/2/2/entrez SP - 601 EP - 4 JF - Bulletin of experimental biology and medicine JO - Bull Exp Biol Med VL - 143 IS - 5 N2 - Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to "calcium" stress. SN - 0007-4888 UR - https://www.unboundmedicine.com/medline/citation/18239779/Effects_of_semax_and_its_Pro_Gly_Pro_fragment_on_calcium_homeostasis_of_neurons_and_their_survival_under_conditions_of_glutamate_toxicity_ DB - PRIME DP - Unbound Medicine ER -