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Dendritic morphology on neurons from prefrontal cortex, hippocampus, and nucleus accumbens is altered in adult male mice exposed to repeated low dose of malathion.
Synapse. 2008 Apr; 62(4):283-90.S

Abstract

Malathion is a highly neurotoxic pesticide widely used in daily life. Acute and chronic toxicity from this organophosphorus compound may cause damage to health, especially to the central nervous system. In the present work, we show the effects of chronic exposure of malathion on dendritic morphology of neurons from prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAcc) in adult male mice. Animals were injected i.p. with low dose of malathion (40 mg/kg body weight) for 14 days. Control animals were injected with corn oil, used as vehicle. Fourteen days after the last injection, brains were removed and processed by the Golgi-Cox stain method, and coronal sections were obtained to perform Sholl analysis on pyramidal neurons from the PFC, CA1 area from the hippocampus, and medium spiny cells from the NAcc. Dendritic morphology analysis included the total dendritic length, the maximum branching order, and the dendritic spine density. Results indicated a significant decrement on dendritic morphology in neurons from the hippocampus and the PFC in animals injected with malathion, whereas medium spiny neurons from NAcc showed a significant decrement only on the dendritic spine density in malathion injected mice, as compared to control mice. These results suggest that chronic toxicity of malathion alters the dendritic morphology in adult age, which may affect behavior.

Authors+Show Affiliations

Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Puebla, México.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18240323

Citation

Campaña, Alba Delia, et al. "Dendritic Morphology On Neurons From Prefrontal Cortex, Hippocampus, and Nucleus Accumbens Is Altered in Adult Male Mice Exposed to Repeated Low Dose of Malathion." Synapse (New York, N.Y.), vol. 62, no. 4, 2008, pp. 283-90.
Campaña AD, Sanchez F, Gamboa C, et al. Dendritic morphology on neurons from prefrontal cortex, hippocampus, and nucleus accumbens is altered in adult male mice exposed to repeated low dose of malathion. Synapse. 2008;62(4):283-90.
Campaña, A. D., Sanchez, F., Gamboa, C., Gómez-Villalobos, M. d. e. . J., De La Cruz, F., Zamudio, S., & Flores, G. (2008). Dendritic morphology on neurons from prefrontal cortex, hippocampus, and nucleus accumbens is altered in adult male mice exposed to repeated low dose of malathion. Synapse (New York, N.Y.), 62(4), 283-90. https://doi.org/10.1002/syn.20494
Campaña AD, et al. Dendritic Morphology On Neurons From Prefrontal Cortex, Hippocampus, and Nucleus Accumbens Is Altered in Adult Male Mice Exposed to Repeated Low Dose of Malathion. Synapse. 2008;62(4):283-90. PubMed PMID: 18240323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dendritic morphology on neurons from prefrontal cortex, hippocampus, and nucleus accumbens is altered in adult male mice exposed to repeated low dose of malathion. AU - Campaña,Alba Delia, AU - Sanchez,Fremioht, AU - Gamboa,Citlalli, AU - Gómez-Villalobos,Ma De Jesús, AU - De La Cruz,Fidel, AU - Zamudio,Sergio, AU - Flores,Gonzalo, PY - 2008/2/2/pubmed PY - 2008/6/5/medline PY - 2008/2/2/entrez SP - 283 EP - 90 JF - Synapse (New York, N.Y.) JO - Synapse VL - 62 IS - 4 N2 - Malathion is a highly neurotoxic pesticide widely used in daily life. Acute and chronic toxicity from this organophosphorus compound may cause damage to health, especially to the central nervous system. In the present work, we show the effects of chronic exposure of malathion on dendritic morphology of neurons from prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAcc) in adult male mice. Animals were injected i.p. with low dose of malathion (40 mg/kg body weight) for 14 days. Control animals were injected with corn oil, used as vehicle. Fourteen days after the last injection, brains were removed and processed by the Golgi-Cox stain method, and coronal sections were obtained to perform Sholl analysis on pyramidal neurons from the PFC, CA1 area from the hippocampus, and medium spiny cells from the NAcc. Dendritic morphology analysis included the total dendritic length, the maximum branching order, and the dendritic spine density. Results indicated a significant decrement on dendritic morphology in neurons from the hippocampus and the PFC in animals injected with malathion, whereas medium spiny neurons from NAcc showed a significant decrement only on the dendritic spine density in malathion injected mice, as compared to control mice. These results suggest that chronic toxicity of malathion alters the dendritic morphology in adult age, which may affect behavior. SN - 0887-4476 UR - https://www.unboundmedicine.com/medline/citation/18240323/Dendritic_morphology_on_neurons_from_prefrontal_cortex_hippocampus_and_nucleus_accumbens_is_altered_in_adult_male_mice_exposed_to_repeated_low_dose_of_malathion_ L2 - https://doi.org/10.1002/syn.20494 DB - PRIME DP - Unbound Medicine ER -