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[Clinical diagnosis and treatment of acute fatty liver of pregnancy].
Zhonghua Fu Chan Ke Za Zhi. 2007 Oct; 42(10):658-61.ZF

Abstract

OBJECTIVE

To study the clinical diagnosis and treatment of acute fatty liver of pregnancy (AFLP).

METHOD

The clinical data of 36 cases of AFLP were reviewed retrospectively, who were treated during Jan 1988- July 2007 in the Department of Obstetrics and Gynecology, Public Health Clinical Center Affiliated to Fu Dan University, Shanghai.

RESULTS

All 36 cases were hospitalized in late pregnancy with various clinical symptoms and physical signs. Lab examinations were also performed. In the case of natural delivery, the rate of postpartum hemorrhage, and maternal mortality were 42%, and 50%, and the perinatal mortality and asphyxia in newborns were 50% and 58% respectively. In the case of cesarean section, the rate was 42%, 8%, and 13%, 38% respectively. The comprehensive therapies of termination of pregnancy by cesarean section plus medical supportive treatment can reduce the rate of postpartum hemorrhage, maternal mortality, perinatal mortality, and asphyxia in newborns significantly. Compared with the natural delivery, cesarean section had the higher rate of postpartum hemorrhage and the rate of asphyxia in newborns (P > 0.05), higher rate of maternal mortality and perinatal mortality (P < 0.05). All the death cases occurred in patients who only began to receive treatment 7 days after presentation of the symptoms. Compared with B ultrasonography, of which diagnosis rate of AFLP was 57%, CT had a higher diagnosis rate of 73% (P < 0.05).

CONCLUSION

Early diagnosis, termination of pregnancy by cesarean section as soon as possible and a comprehensive therapy are the key to improve the mother and newborn's prognosis.

Authors+Show Affiliations

Jiang PR
Department of Obstetrics and Gynecology, Shanghai Public Health Clinical Center, Shanghai, China. jiangpeiru@shaphc.org
Zhang XH
No affiliation info available
Zhang QY
No affiliation info available
Lin Y
No affiliation info available
Gu H
No affiliation info available

MeSH

Acute DiseaseAdultBilirubinCesarean SectionFatty LiverFemaleHumansInfant, NewbornPregnancyPregnancy ComplicationsPregnancy OutcomeRetrospective StudiesTransaminases

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18241538

Citation

Jiang, Pei-Ru, et al. "[Clinical Diagnosis and Treatment of Acute Fatty Liver of Pregnancy]." Zhonghua Fu Chan Ke Za Zhi, vol. 42, no. 10, 2007, pp. 658-61.
Jiang PR, Zhang XH, Zhang QY, et al. [Clinical diagnosis and treatment of acute fatty liver of pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2007;42(10):658-61.
Jiang, P. R., Zhang, X. H., Zhang, Q. Y., Lin, Y., & Gu, H. (2007). [Clinical diagnosis and treatment of acute fatty liver of pregnancy]. Zhonghua Fu Chan Ke Za Zhi, 42(10), 658-61.
Jiang PR, et al. [Clinical Diagnosis and Treatment of Acute Fatty Liver of Pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2007;42(10):658-61. PubMed PMID: 18241538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical diagnosis and treatment of acute fatty liver of pregnancy]. AU - Jiang,Pei-Ru, AU - Zhang,Xiao-Hong, AU - Zhang,Qing-Ying, AU - Lin,Ying, AU - Gu,Hang, PY - 2008/2/5/pubmed PY - 2008/10/22/medline PY - 2008/2/5/entrez SP - 658 EP - 61 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 42 IS - 10 N2 - OBJECTIVE: To study the clinical diagnosis and treatment of acute fatty liver of pregnancy (AFLP). METHOD: The clinical data of 36 cases of AFLP were reviewed retrospectively, who were treated during Jan 1988- July 2007 in the Department of Obstetrics and Gynecology, Public Health Clinical Center Affiliated to Fu Dan University, Shanghai. RESULTS: All 36 cases were hospitalized in late pregnancy with various clinical symptoms and physical signs. Lab examinations were also performed. In the case of natural delivery, the rate of postpartum hemorrhage, and maternal mortality were 42%, and 50%, and the perinatal mortality and asphyxia in newborns were 50% and 58% respectively. In the case of cesarean section, the rate was 42%, 8%, and 13%, 38% respectively. The comprehensive therapies of termination of pregnancy by cesarean section plus medical supportive treatment can reduce the rate of postpartum hemorrhage, maternal mortality, perinatal mortality, and asphyxia in newborns significantly. Compared with the natural delivery, cesarean section had the higher rate of postpartum hemorrhage and the rate of asphyxia in newborns (P > 0.05), higher rate of maternal mortality and perinatal mortality (P < 0.05). All the death cases occurred in patients who only began to receive treatment 7 days after presentation of the symptoms. Compared with B ultrasonography, of which diagnosis rate of AFLP was 57%, CT had a higher diagnosis rate of 73% (P < 0.05). CONCLUSION: Early diagnosis, termination of pregnancy by cesarean section as soon as possible and a comprehensive therapy are the key to improve the mother and newborn's prognosis. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/18241538/[Clinical_diagnosis_and_treatment_of_acute_fatty_liver_of_pregnancy]_ DB - PRIME DP - Unbound Medicine ER -