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Lipid transfer protein in diagnosis of birch-apple syndrome in children.
Immunobiology. 2008; 213(2):89-96.I

Abstract

Lipid transfer protein (LTP) has been reported as an important allergen inducing severe systemic reactions in allergic subjects. The aim of the present study was to estimate the role of LTP in diagnosis of apple allergy in children allergic to birch pollen. The prospective study was carried out on a group of 21 children sensitized to birch pollen and apple allergens, confirmed by presence of specific IgE in the sera of patients. Allergens separated by electrophoresis were probed by Western blotting using hypersensitive patients' sera. Food hypersensitivity to apple was verified by oral food challenge test. Six patients' sera were hypersensitive to birch pollen and apple proteins. Almost all sera recognized specifically the main allergen of apple peal Mal d 3 with molecular weight <10kDa (LTP). Positive oral challenge to apple was found in 52.4% of investigated children. Children allergic to Mal d 1 presented different clinical symptoms. Sensitization to Mal d 3 is very common in children with apple allergy. No correlation between clinical symptoms and sensitization to recombinant apple allergens has been found, LTP may be useful in diagnosis of apple allergy.

Authors+Show Affiliations

III Department of Paediatrics, Medical University of Bialystok, Ul. Waszyngtona 17, 15-274 Bialystok, Poland. becud@wp.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18241693

Citation

Cudowska, Beata, et al. "Lipid Transfer Protein in Diagnosis of Birch-apple Syndrome in Children." Immunobiology, vol. 213, no. 2, 2008, pp. 89-96.
Cudowska B, Kaczmarski M, Restani P. Lipid transfer protein in diagnosis of birch-apple syndrome in children. Immunobiology. 2008;213(2):89-96.
Cudowska, B., Kaczmarski, M., & Restani, P. (2008). Lipid transfer protein in diagnosis of birch-apple syndrome in children. Immunobiology, 213(2), 89-96. https://doi.org/10.1016/j.imbio.2007.07.006
Cudowska B, Kaczmarski M, Restani P. Lipid Transfer Protein in Diagnosis of Birch-apple Syndrome in Children. Immunobiology. 2008;213(2):89-96. PubMed PMID: 18241693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid transfer protein in diagnosis of birch-apple syndrome in children. AU - Cudowska,Beata, AU - Kaczmarski,Maciej, AU - Restani,Patrizia, Y1 - 2007/09/10/ PY - 2006/09/07/received PY - 2007/06/15/revised PY - 2007/07/17/accepted PY - 2008/2/5/pubmed PY - 2008/5/14/medline PY - 2008/2/5/entrez SP - 89 EP - 96 JF - Immunobiology JO - Immunobiology VL - 213 IS - 2 N2 - Lipid transfer protein (LTP) has been reported as an important allergen inducing severe systemic reactions in allergic subjects. The aim of the present study was to estimate the role of LTP in diagnosis of apple allergy in children allergic to birch pollen. The prospective study was carried out on a group of 21 children sensitized to birch pollen and apple allergens, confirmed by presence of specific IgE in the sera of patients. Allergens separated by electrophoresis were probed by Western blotting using hypersensitive patients' sera. Food hypersensitivity to apple was verified by oral food challenge test. Six patients' sera were hypersensitive to birch pollen and apple proteins. Almost all sera recognized specifically the main allergen of apple peal Mal d 3 with molecular weight <10kDa (LTP). Positive oral challenge to apple was found in 52.4% of investigated children. Children allergic to Mal d 1 presented different clinical symptoms. Sensitization to Mal d 3 is very common in children with apple allergy. No correlation between clinical symptoms and sensitization to recombinant apple allergens has been found, LTP may be useful in diagnosis of apple allergy. SN - 0171-2985 UR - https://www.unboundmedicine.com/medline/citation/18241693/Lipid_transfer_protein_in_diagnosis_of_birch_apple_syndrome_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0171-2985(07)00087-3 DB - PRIME DP - Unbound Medicine ER -